| Company Name: |
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
| Products Intro: |
Product Name:( R )-CPP
CAS:126453-07-4
Package:10mg, 50mg
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| | (R)-CPP Basic information |
| Product Name: | (R)-CPP | | Synonyms: | (R)-CPP;(R)-CCP;R(-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID;D-CPP;3-((R)-2-CARBOXYLPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID;3-((R)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID;3-((R)-Carboxylpiperazin-4-yl)-propyl-1-phosphonic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid | | CAS: | 126453-07-4 | | MF: | C8H17N2O5P | | MW: | 252.2 | | EINECS: | | | Product Categories: | Glutamate;Glutamate receptor | | Mol File: | 126453-07-4.mol |  |
| | (R)-CPP Chemical Properties |
| Boiling point | 546.7±60.0 °C(Predicted) | | density | 1.408±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at RT | | solubility | Water: 100mM | | form | White crystalline powder. | | pka | 1.89±0.20(Predicted) | | Water Solubility | Soluble to 100 mM in water |
| | (R)-CPP Usage And Synthesis |
| Description | (R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg). | | Uses | (R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism. | | Biological Activity | Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively). | | storage | Room temperature (desiccate) |
| | (R)-CPP Preparation Products And Raw materials |
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