| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-Caspase 3, Active antibody produced in rabbit
Purity:IgG fraction of antiserum, buffered aqueous solution Package:200UL Remarks:C8487-200UL
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| Company Name: |
Shanghai Bohu Biotechnology Co., LTD
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| Tel: |
021-57763112 13585886131 |
| Email: |
3004987436@qq.com |
| Products Intro: |
Product Name:Anti-Caspase-3
Purity:1mg/1ml Package:100ug/;200ug/
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| | ANTI-CASPASE-3 Basic information |
| Product Name: | ANTI-CASPASE-3 | | Synonyms: | ANTI-CASPASE-3 (AB-2);ANTI-CASPASE-3 (AB-2), HUMAN;ANTI-CASPASE-3 (AB-2) MOUSE MAB;ANTI-CASPASE-3 (AB-3);ANTI-CASPASE-3 (AB-3), HUMAN;ANTI-CASPASE-3 (AB-3) MOUSE MAB;ANTI-CASPASE-3 (AB-4), HUMAN;ANTI-CASPASE-3 (AB-4) MOUSE MAB | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-CASPASE-3 Structure]() |
| | ANTI-CASPASE-3 Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder |
| | ANTI-CASPASE-3 Usage And Synthesis |
| Uses | Anti-Caspase 3, Active antibody has been used:
- for western blotting of cytochrome c for caspase activation
- as primary antibody in immunofluorescence staining of embryos and postnatal mice cryosections
- in Western blot analysis of activated caspase 3
- as a primary antibody in immunodetection of rat brain sections
| | General Description | Caspase-3 (CASP3) belongs to the class of cysteine proteases. CASP3?is an executioner caspase, which is cleaved and activated with the help of caspase-8 and caspase-9 initiator caspases. CASP3?is mapped to human chromosome 4q35.1. | | Biochem/physiol Actions | Caspase 3 is one of the key effectors of apoptosis. It acts downstream of caspase 9 in the apoptotic pathway. During apoptosis, it gets activated by proteolytic cleavage into the 17-19 kDa (p17, p18) and 12 kDa (p12) active subunits. Any alteraion in CASP-3 in mice, causes premature lethality. It has also shown that the deletion of gene affects brain development resulting of hyperplasias and disorganized cell deployement. Clinically it is related to Huntington disease (HD). Caspase 3 brings about cell death by activating CAD (caspase activated DNAse I), an endonuclease that causes degradation of chromosomal DNA. |
| | ANTI-CASPASE-3 Preparation Products And Raw materials |
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