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| | 3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester Basic information |
| Product Name: | 3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester | | Synonyms: | 3-METHYL-2-NITRO-3H-IMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER;Methyl 3-methyl-2-nitro-3H-imidazole-4-carboxylate;1H-Imidazole-5-carboxylic acid, 1-methyl-2-nitro-, methyl ester;methyl 1-methyl-2-nitro-imidazole-5-carboxylate;3-methyl-2-nitro-4-imidazolecarboxylic acid methyl ester;3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid | | CAS: | 40361-79-3 | | MF: | C6H7N3O4 | | MW: | 185.14 | | EINECS: | | | Product Categories: | | | Mol File: | 40361-79-3.mol |  |
| | 3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester Chemical Properties |
| Boiling point | 374.6±34.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -1.69±0.25(Predicted) |
| | 3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester Usage And Synthesis |
| Synthesis | 1-methyl-2-nitro-1H-imidazole-5-carboxylic acid methyl ester 1c (50g, 0.27mol) was dissolve in 500mL tetrahydrofuran, followed by dropwise add methanol (13g, 0.4mol, 1.5eq) at 0 ℃. A solution of lithium hydride in tetrahydrofuran (2M, 202 mL, 1.5 eq) was added, and the reaction was incubated at 0 ℃ for 1 hour. The reaction solution was quenched by adding 500 mL of water, and extracted with ethyl acetate (500 mL × 3). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was added with dichloromethane (200 mL) and filtered to obtain 3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester(31 g, 0.2 mol, yellow solid), yield: 73%.
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| | 3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester Preparation Products And Raw materials |
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