TETRAMETHYLSUCCINONITRILE

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Products Intro: Product Name:3333-52-6
CAS:3333-52-6
Purity:99% Package:25KG;5KG;1KG
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Products Intro: Product Name:2,2,3,3-Tetramethylsuccinonitrile
CAS:3333-52-6
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-55244
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Products Intro: Product Name:Tetramethylsuccinonitrile
CAS:3333-52-6
Purity:98%;crystal 604 Package:1KG;0.01USD
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CAS:3333-52-6
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Products Intro: Product Name:TETRAMETHYLSUCCINONITRILE
CAS:3333-52-6
TETRAMETHYLSUCCINONITRILE Basic information
Product Name:TETRAMETHYLSUCCINONITRILE
Synonyms:Butanedinitrile, tetramethyl-;butanedinitrile,tetramethyl-;Butanedinitrile,tetramethyl-(9CI);cp75475;Succinonitrile, tetramethyl-;succinonitrile,tetramethyl-;tetramethyl-butanedinitril;Tetramethylsuccinic acid dinitrile
CAS:3333-52-6
MF:C8H12N2
MW:136.19
EINECS:604-604-1
Product Categories:Fine Chemicals;Dinitriles;Dinitriles & Trinitriles
Mol File:3333-52-6.mol
TETRAMETHYLSUCCINONITRILE Structure
TETRAMETHYLSUCCINONITRILE Chemical Properties
Melting point 168°C
Boiling point 240.49°C (rough estimate)
density 1.0700
refractive index 1.4436 (estimate)
storage temp. Sealed in dry,Room Temperature
Water Solubility Insoluble in water
solubility Chloroform (Soluble), DMSO (Slightly)
form solid
color White to Almost white
EPA Substance Registry SystemTetramethylsuccinonitrile (3333-52-6)
Safety Information
Hazard Codes T
Risk Statements 23/24/25-36/37/38-48/20/21
Safety Statements 26-36/37/39-45-36/37
RIDADR 3439
OEBB
OELTWA: 3 mg/m3 (0.5 ppm) [skin]
WGK Germany 3
RTECS WN4025000
HS Code 2926.90.5050
HazardClass 6.1(a)
PackingGroup II
Hazardous Substances Data3333-52-6(Hazardous Substances Data)
IDLA5 ppm
MSDS Information
TETRAMETHYLSUCCINONITRILE Usage And Synthesis
Chemical PropertiesColorless, solid; odorless. Insoluble in water.
UsesBlowing agent for vinyl foam production.
Uses2,2,3,3-Tetramethylsuccinonitrile is used in preparation of 4,5-Dihydro-1,2,3-triazole derivatives as Farnesyltransferase inhibitors.
Uses2,2,3,3-Tetramethylsuccinonitrile can be used as a reactant to synthesize:
  • 3,4-Dihydro-3H-pyrrol-2-imines by reacting with aryl lithium species in the presence of TMSCl.
  • Phenyl substituted metal-free fused tetraazachlorins by condensation reaction with substituted phthalonitrile derivatives in the presence of InCl3.

Synthesis Reference(s)Journal of the American Chemical Society, 87, p. 4403, 1965 DOI: 10.1021/ja00947a046
General DescriptionWhite crystals.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileNitriles, such as TETRAMETHYLSUCCINONITRILE, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. TETRAMETHYLSUCCINONITRILE can react violently with (LiAlH4 + H2O).
HazardToxic by inhalation and skin contact. Headache, nausea, and central nervous system convulsions.
Fire HazardFlash point data are not available for TETRAMETHYLSUCCINONITRILE, but TETRAMETHYLSUCCINONITRILE is probably combustible.
Safety ProfilePoison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. A human skin irritant and allergen. In the preparation of sponge rubber, an azo compound is used that decomposes to form tetramethylsuccinonitrile or TMSN. Rats exposed to a concentration of 90 ppm exhbit their first convulsion after 1.5-2 hours or less. Rats exposed to concentration of 5.5 pprn exhbited their first convulsions in 27-31 hours and were dead in 31-46 hours. Absorbed by skin. The fatal dose in humans is thought to be about 25 mg/kg of body weight. TSN is slowly detoxified by the body. This nitrile is different from other nitriles in that duosulfate is a poor antidote for intoxication. When heated to decomposition it emits toxic fumes of CNand NOx. See also NITRILES and CYANIDE.
TETRAMETHYLSUCCINONITRILE Preparation Products And Raw materials
Raw materialsDIETHYL IODOMETHYLPHOSPHONATE-->TETRAETHYL ETHYLENEDIPHOSPHONATE-->Diethyl methylphosphonate-->1-Hexene-->2,2'-Azobis(2-methylpropionitrile)
Tag:TETRAMETHYLSUCCINONITRILE(3333-52-6) Related Product Information
TETRAMETHYLAMMONIUM HYDROGENSULFATE 2,2,6,6-Tetramethyl-4-piperidinol 1,1,3,3-Tetramethyldisilazane TETRAMETHYL-1,3-CYCLOBUTANEDIONE (S,S)-(-)-2,3-DIHYDROXY-N,N,N',N'-TETRAMETHYLSUCCINAMIDE Tetramethylammonium nitrate 2,3-Dimethylbutane Succinonitrile SALOR-INT L160822-1EA TETRAMETHYLSUCCINONITRILE SALOR-INT L163473-1EA SALOR-INT L167371-1EA SPECS AN-907/25060014 SALOR-INT L162159-1EA SALOR-INT L166081-1EA