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| | (R)-4-Benzyl-2-oxazolidinone Basic information |
| | (R)-4-Benzyl-2-oxazolidinone Chemical Properties |
| Melting point | 88-90 °C | | alpha | 62 º (C=1, CHCl3) | | Boiling point | 309.12°C (rough estimate) | | density | 1.1607 (rough estimate) | | refractive index | 14.5 ° (C=5, MeOH) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly) | | form | Crystalline Powder | | pka | 12.78±0.40(Predicted) | | color | White to almost white | | optical activity | [α]18/D +64°, c = 1 in chloroform | | Water Solubility | Insoluble in water. Soluble in Chloroform. | | Sensitive | Hygroscopic | | BRN | 4782551 | | CAS DataBase Reference | 102029-44-7(CAS DataBase Reference) |
| | (R)-4-Benzyl-2-oxazolidinone Usage And Synthesis |
| Description | (R)-4-Benzyl-2-oxazolidinone is a derivative of oxazolidinone. It
can be used in the preparation of enantiopure carbocyclic
nucleosides, which act as a HIV protease inhibitor. It can also be
used as a chiral auxiliary in the enantioselective synthesis of (2R,
2′S)-erythro-methylphenidate, beta-lactams and alpha-amino acids.
Its end product includes asymmetric single isomeric drugs such as
antitumor, anesthetic and entipasmodic products. | | Chemical Properties | white to light yellow crystal powde | | Uses | (R)-(+)-4-Benzyl-2-oxazolidinones are used in the enantioselective synthesis of beta-lactams and alpha-amino acids. End products can include asysmmetric single isomeric drugs of antitumor, anesthetic, antipasmodic products. Used in the synthesis of HIV protease inhibitors. An oxazolidinone used in chiral auxiliary asymetric synthesis. | | Uses | intermediate for Aliskiren hemifumarate, Darifenacin HBr, Zolmitriptan | | References | http://www.sigmaaldrich.com/catalog/product/aldrich/300977? lang=en®ion=US
https://www.alfa.com/en/catalog/A16770/ Shieh, Wen Chung, et al. "Synthesis of enantiomerically enriched 4- piperidinylglycine." US, US 6670477B2. 2003. |
| | (R)-4-Benzyl-2-oxazolidinone Preparation Products And Raw materials |
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