| Company Name: |
Adamas Reagent, Ltd.
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400-6009262 16621234537 |
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zhangsn@titansci.com |
| Products Intro: |
Product Name:Baclofen-d4
CAS:1189938-30-4
Purity:对照品 Package:10mg~500mg Remarks:AC000944D01
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| Company Name: |
Shanghai Kewel Chemical Co., Ltd.
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| Tel: |
021-64609169 18901607656 |
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greensnown@163.com |
| Products Intro: |
Product Name:Baclofen-d4
CAS:1189938-30-4
Purity:95+ HPLC; Package:10mg;25mg;50mg;100mg
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Baclofen-d4 manufacturers
- Baclofen-D4
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- $0.00 / 5mg
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2023-05-27
- CAS:1189938-30-4
- Min. Order: 1mg
- Purity: 96%
- Supply Ability: 50 mg
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| | Baclofen-d4 Basic information |
| Product Name: | Baclofen-d4 | | Synonyms: | (±)-Baclofen-d4 (4-chlorophenyl-d4);Baclofen D4 HydrochlorideQ: What is
Baclofen D4 Hydrochloride Q: What is the CAS Number of
Baclofen D4 Hydrochloride Q: What is the storage condition of
Baclofen D4 Hydrochloride Q: What are the applications of
Baclofen D4 Hydrochloride;[2H4]-Baclofen;(+/-)-BACLOFEN (D4, 98%) 100 UG/ML IN METHANOL | | CAS: | 1189938-30-4 | | MF: | C10H8D4ClNO2 | | MW: | 217.685427112 | | EINECS: | | | Product Categories: | | | Mol File: | 1189938-30-4.mol |  |
| | Baclofen-d4 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Water: soluble | | form | A solid | | Water Solubility | Water: soluble |
| | Baclofen-d4 Usage And Synthesis |
| Uses | Specific GABA-B receptor agonist. Muscle relaxant (skeletal). | | Biological Activity | (±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury. | | References | 1.Hill, D.R., and Bowery, N.G.3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brainNature290(5802)(1981)
2.Biscoe, T.J., and Fry, J.P.Some pharmacological studies on the spastic mouseBr. J. Pharmacol. 75(1)23-25(1982)
3.Sakitani, K.The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in ratsJpn. J. Pharmacol.63(3)369-376(1993)
4.Lhuillier, L., Mombereau, C., Cryan, J.F., et al.GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaineNeuropsychopharmacology32(2)388-398(2007)
5.Moore, E.M., and Boehm, S.L., IISite-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J miceBehav. Neurosci.123(3)555-563(2009) |
| | Baclofen-d4 Preparation Products And Raw materials |
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