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Pterostilbene

Pterostilbene Suppliers list
Company Name: Shaanxi Pioneer Biotech Co., Ltd .
Tel: +8613259417953
Email: sales@pioneerbiotech.com
Products Intro: Product Name:Pterostilbene
CAS:537-42-8
Purity:0.99 Package:5KG;1KG
Company Name: PNP Biotech Co. Ltd
Tel: +8618516098983
Email: sales@pnpbiotech.com
Products Intro: Product Name:Pterostilbene
CAS:537-42-8
Purity:99.75% Package:25kg;0.00;USD
Company Name: Shaanxi Haibo Biotechnology Co., Ltd
Tel: +undefined18602966907
Email: qinhe02@xaltbio.com
Products Intro: Product Name:Pterostilbene
CAS:537-42-8
Purity:99% Package:1KG;|100KG;|1000KG Remarks:White Powder
Company Name: Beri Pharma Co., Ltd.
Tel: +8613417710166
Email: sales@zhberi.com
Products Intro: Product Name:Pterostilbene
CAS:537-42-8
Purity:99% Package:25KG;1KG Remarks:Professional manufacturer of cosmetic ingredient;supplier of Chinese top cosmetic companies
Company Name: Hengshui Haoye Co.,Ltd.
Tel: +86-2102300 +86-18632882519
Email: hy@haoyecom.cn
Products Intro: Product Name:Pterostilbene
CAS:537-42-8

Pterostilbene manufacturers

  • Pterostilbene
  • Pterostilbene pictures
  • $40.00 / 20mg
  • 2024-10-31
  • CAS:537-42-8
  • Min. Order:
  • Purity: 99.71%
  • Supply Ability: 10g
  • Pterostilbene
  • Pterostilbene pictures
  • $200.00 / 1kg
  • 2024-10-31
  • CAS:537-42-8
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 20ton
  • Pterostibene
  • Pterostibene pictures
  • $0.00 / 25KG
  • 2024-10-31
  • CAS:537-42-8
  • Min. Order: 2KG
  • Purity: 99% up
  • Supply Ability: 20 tons

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Question and answer

Pterostilbene Basic information
Product Name:Pterostilbene
Synonyms:AKOS 236-80;3,5-DIMETHOXY-4'-HYDROXYSTILBENE;3',5'-DIMETHOXY-4-STILBENOL;4-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]PHENOL;PTEROSTILBENE;PTEROCARPUS MARSUPIUM;TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE;(E)-3,5-Dimethoxy-4'-hydroxystilbene
CAS:537-42-8
MF:C16H16O3
MW:256.3
EINECS:611-041-4
Product Categories:chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Herb extract;Health supplements;Inhibitors;API;537-42-8
Mol File:537-42-8.mol
Pterostilbene Structure
Pterostilbene Chemical Properties
Melting point 89-92 ºC
Boiling point 420.4±35.0 °C(Predicted)
density 1.169±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
pka9.96±0.26(Predicted)
form solid
color White or off-white
OdorCharacteristic
λmax321nm(MeOH)(lit.)
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
InChIInChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
InChIKeyVLEUZFDZJKSGMX-ONEGZZNKSA-N
SMILESC1(O)=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1
LogP4.056 (est)
Safety Information
Hazard Codes Xi,N
Risk Statements 41-51/53
Safety Statements 26-39-61
RIDADR 3077
WGK Germany 3
HazardClass IRRITANT
PackingGroup 
HS Code 29095000
MSDS Information
Pterostilbene Usage And Synthesis
DescriptionPterostilbene (PTS) is a fragrant-smelling hydrocarbon called "styrene", which is a derivative of resveratrol. It is found in blueberries and Pterocarpus marsupium (PM) heartwood. Similar to resveratrol, PTS has anti-inflammatory, anti-thrombotic, anti-cancer, anti-cancer, anti-hyperlipidemia and antibacterial effects.
Chemical PropertiesPterostilbene is a white crystalline powder, sensitive to air, soluble in hot methanol, DMSO, insoluble in water. It is a stilbenoid chemically similar to resveratrol and from the leguminous plant Pterocarpus indicus.
OccurrencePterostilbene is a natural molecule found in fruits, vegetables and nuts. Blueberries are often quoted as one of the richest sources of pterostilbene. It is also found in almonds,various Vaccinium berries (including blueberries), grape leaves and vines,and Pterocarpus marsupium heartwood.
UsesSubstantial studies demonstrate that pterostilbene has diverse pharmacological activities for the prevention and treatment of diseases including inflammation, cancer, diabetes, and dyslipidemia.
Pterostilbene has been used:
to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)
PreparationPterostilbene was synthesized from 3,5-dimethoxybenzyl bromide and p-nitrobenzaldehyde by Witting-Hornor reaction, reduction, diazotization and hydrolysis, with a total yield of 53.9%.
synthesis of Pterostilbene
DefinitionChEBI: Pterostilbene is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'. It has a role as an antioxidant, an antineoplastic agent, a neurotransmitter, a plant metabolite, an apoptosis inducer, a neuroprotective agent, an anti-inflammatory agent, a radical scavenger and a hypoglycemic agent. It is a stilbenol, a member of methoxybenzenes and a diether. It derives from a hydride of a trans-stilbene.
benefitsPterostilbene is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Pterostilbene is known to have many pharmacological benefits for the prevention and treatment of a wide variety of diseases, including ( cancer (McCormack and McFadden 2012), dyslipidaemia (Rimando et al. 2005), diabetes (Amarnath Satheesh and Pari 2006), cardiovascular degeneration (Amarnath Satheesh and Pari 2008) and pain (Hougee et al. 2005).
Biological ActivityA cell-permeable methoxylated analog of Resveratrol that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox. Moderately inhibits COX-1 & COX-2 activities (IC50 = 19.8 μM & 83.9 μM, respectively) and induces apoptosis in HL60 cells (IC50 = 70 μM). Also prevents DMBA-induced pre-neoplastic lesions (ED50 = 4.8 μM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.
Side effectsThe side effects of pterostilbene are relatively minor, but you still need to pay attention to the dosage. Low-dose pterostilbene supplementation improves cholesterol metabolism and reduces triglyceride levels. Side effects include mild weight loss and muscle pain, but dose adjustment is usually not necessary.
References[1] ESTRELAJOSé M. Pterostilbene: Biomedical applications.[J]. Critical reviews in clinical laboratory sciences, 2013. DOI:10.3109/10408363.2013.805182.
[2] HYUNSOOK KIM  Wallace Y  Kun Ho Seo. Chemistry of Pterostilbene and Its Metabolic Effects[J]. Journal of Agricultural and Food Chemistry, 2020. DOI:10.1021/acs.jafc.0c00070.
[3] MACICKOVATATIANA. In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis.[J]. Neuro endocrinology letters, 2010.
[4] WASAMON NUTAKUL. Inhibitory Effects of Resveratrol and Pterostilbene on Human Colon Cancer Cells: A Side-by-Side Comparison[J]. Journal of Agricultural and Food Chemistry, 2011. DOI:10.1021/jf202846b.
Pterostilbene Preparation Products And Raw materials
Raw materials4-Nitrobenzaldehyde-->3,5-DIMETHOXYBENZYL BROMIDE
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