SURAMIN
| 中文名称 | SURAMIN |
|---|---|
| 中文同义词 | 舒拉明;苏拉灭;苏拦明 |
| 英文名称 | 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid |
| 英文同义词 | 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid;Farma 939;Fourneau;Naphuride;Suramine;129-46-4(Hexasodium salt);8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid;Aids000067 |
| CAS号 | 145-63-1 |
| 分子式 | C51H40N6O23S6 |
| 分子量 | 1297.28 |
| EINECS号 | 205-658-4 |
| 相关类别 | |
| Mol文件 | 145-63-1.mol |
| 结构式 |  |
SURAMIN 性质
| 熔点 | 128 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| 密度 | 1.2629 (rough estimate) |
| 折射率 | 1.7770 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | -1.35±0.40(Predicted) |
| 颜色 | 粉白色吸湿性粉末 |
| EPA化学物质信息 | Suramin (145-63-1) |
|
SIRT1 297 nM (IC 50 ) |
SIRT2 1.15 μM (IC 50 ) |
SIRT5 22 μM (IC 50 ) |
Suramin (50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells.
Suramin (300 μg/mL; for 48 hours) induces cells apoptosis, and down-regulates mRNA expression in HeLa cells.
Suramin (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2.
The IC
50
values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively.
Suramin blocks viral replication in Vero E6 cells.
Cell Proliferation Assay
| Cell Line: | HO-8910 PM ovarian and Hela cervical cancer cells |
| Concentration: | 50, 100, 200, 300, 400, 500 and 600 μg/mL |
| Incubation Time: | For 24, 48, 72 and 96 hours |
| Result: | Inhibited cells proliferation in a dose-dependent and time-dependent manner. |
Apoptosis Analysis
| Cell Line: | HeLa cells |
| Concentration: | 300 μg/mL |
| Incubation Time: | For 48 hours |
| Result: | Induced cells apoptosis. |
Western Blot Analysis
| Cell Line: | PA-SMCs cells |
| Concentration: | 1 mg/mL |
| Incubation Time: | For 1 hours |
| Result: | Significantly suppressed the phosphorylated ERK1/2. |
Suramin (10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure.
| Animal Model: | Adult male Wistar rats (200-225 g) |
| Dosage: | 10 mg/kg |
| Administration: | IV; twice weekly for 3 weeks |
| Result: | Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure. |
安全信息
| 毒性 | LD50 intravenous in mouse: 620mg/kg |
|---|