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PJ-34

PJ-34 Suppliers list
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008657128800458; +8615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:PJ34;PJ-34
CAS:344458-15-7
Purity:As coa Package:As request Remarks:344458-15-7
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:PJ-34
CAS:344458-15-7
Purity:0.99 Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:PJ34
CAS:344458-15-7
Package:100mg Remarks:BOC Sciences also provides custom synthesis services for PJ34.
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Products Intro: Product Name:PJ34 HCl
CAS:344458-15-7
Purity:98% Package:Package as requetsed
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PJ34 hydrochloride;PJ34 HCl
CAS:344458-15-7
Purity:99.9% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;25 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
PJ-34 Basic information
Product Name:PJ-34
Synonyms:PJ 34 Hydrochloride;N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride;PARP Inhibitor VIII, PJ34;PJ-34 hydrate hydrochloride;AcetaMide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)-, hydrochloride;N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)acetaMide;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride;N,N-diMethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride
CAS:344458-15-7
MF:C17H17N3O2HCl
MW:0
EINECS:
Product Categories:Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:344458-15-7.mol
PJ-34 Structure
PJ-34 Chemical Properties
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility H2O: soluble22mg/mL
form White solid
color white to yellow
Sensitive Light Sensitive & Hygroscopic
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29339900
MSDS Information
PJ-34 Usage And Synthesis
DescriptionPJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM.1?Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia mouse model.3 PJ-34 HCl causes PARP1 independent, p21 dependent mitotic arrest.4
UsesA poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7.
UsesPJ-34 hydrochloride hydrate has been used:
  • as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
  • as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
  • as PARP inhibitor in murine MLE-12 epithelial cell line

DefinitionChEBI: PJ34 hydrochloride is a hydrochloride salt prepared from equimolar amounts of PJ34 and hydrochloric acid. It has a role as an angiogenesis inhibitor, an anti-inflammatory agent, an antiatherosclerotic agent, an antineoplastic agent, an apoptosis inducer, a cardioprotective agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and a neuroprotective agent. It contains a PJ34(1+).
General DescriptionA cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).
Biological ActivityPotent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide . Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo .
Biochem/physiol ActionsCell permeable: yes
storage+4°C
References1) Pellicciari et al. (2008), On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem., 3 914 2) Crawford et al. (2010), Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model; Surgery, 148 110 3) Haddad et al. (2006), Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice; Br. J. Pharmacol., 149 23 4) Madison et al. (2011), The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest; DNA Repair, 10 1003
PJ-34 Preparation Products And Raw materials
Tag:PJ-34(344458-15-7) Related Product Information
4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 PF-01367338 PD 0325901 Erlotinib hydrochloride PD 0332991 HCl ABT 263 Olaparib Rucaparib DPQ ABT-888 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 6(5H)-Phenanthridone PJ-34 2'-METHYL-BIPHENYL-2-YLAMINE N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N DIMETHYLACETAMIDE HYDROCHLORIDE HYDRATE