ChemicalBook > Product Catalog >API >Antibiotics >Tetracycline drugs >Chlortetracycline hydrochloride

Chlortetracycline hydrochloride

Chlortetracycline hydrochloride Suppliers list
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +86 13288715578 +8613288715578
Email: sales@hbmojin.com
Products Intro: Product Name:Chlortetracycline hydrochloride
CAS:64-72-2
Purity:99% Package:25KG
Company Name: Hebei Chuanghai Biotechnology Co,.LTD
Tel: +86-13131129325
Email: sales1@chuanghaibio.com
Products Intro: Product Name:Chlortetracycline hydrochloride
CAS:64-72-2
Purity:99 Package:1KG;10.50;USD
Company Name: shandong perfect biotechnology co.ltd
Tel: +86-53169958659; +8618596095638
Email: sales@sdperfect.com
Products Intro: Product Name:Chlortetracyclin hydrochloride
CAS:64-72-2
Purity:98% HPLC Package:1g
Company Name: Shaanxi TNJONE Pharmaceutical Co., Ltd
Tel: +8618092446649
Email: sarah@tnjone.com
Products Intro: Product Name:Tetramisole Hydrochloride
CAS:64-72-2
Purity:99% Package:1KG
Company Name: Apeloa production Co.,Limited
Tel: +8619933239880
Email: admin@apcl.com.cn
Products Intro: Product Name:Chlortetracyclin hydrochloride
CAS:64-72-2
Purity:98% Package:1g;1.00;USD

Chlortetracycline hydrochloride manufacturers

Chlortetracycline hydrochloride Basic information
Product Name:Chlortetracycline hydrochloride
Synonyms:7-CHLORTETRACYCLINE MONOHYDROCHLORIDE;7-CHLOROTETRACYCLINE HCL;7-CHLOROTETRACYCLINE HYDROCHLORIDE;7-CHLOROTETRACYCLINE MONOHYDROCHLORIDE;2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-;CHLOROTETRACYCLINE HYDROCHLORIDEVETRANAL , 250 MG;CHLORTETRACYCLINE HYDROCHLORIDE FROM STR EPTOMYCES AUREOFACI;Aureociclina, Isphamycin
CAS:64-72-2
MF:C22H24Cl2N2O8
MW:515.34
EINECS:200-591-7
Product Categories:AUREOMYCIN;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;64-72-2
Mol File:64-72-2.mol
Chlortetracycline hydrochloride Structure
Chlortetracycline hydrochloride Chemical Properties
Melting point 210-215 °C (dec.)(lit.)
alpha D23 -240°
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility 1 M NaOH: soluble50mg/mL
form Powder
color faint yellow to yellow
pka3.3(at 25℃)
Water Solubility Soluble in water
Sensitive Light Sensitive
Merck 13,2211
BRN 3858364
CAS DataBase Reference64-72-2(CAS DataBase Reference)
EPA Substance Registry SystemChlortetracycline hydrochloride (64-72-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 2
RTECS QI7800000
HazardClass 3
HS Code 29413020
ToxicityLD50 orally in rats: 10300 mg/kg (Goldenthal)
Chlortetracycline hydrochloride Usage And Synthesis
DescriptionChlortetracycline was found in the culture broth of Streptomyces aureofaciens by Duggar et al. of Lederle Laboratories in 1948 and named aureomycin. It shows a wider range of antibiotic activity than the earlier antibiotics, penicillins, and streptomycins and as great as that of chloramphenicol. Its activity covers grampositive and gram-negative bacteria as well as Rickettsia and Chlamydiae. Chlortetracycline has been replaced by other tetracyclines in clinical use and is used now used as a feed additive to promote the growth of livestock.
Chemical PropertiesYellow Solid
UsesChlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
UsesChlortetracycline is an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.
Usesantibacterial, antiamebic, Ca chelator, hepatotoxic; inhibits protein synthesis
UsesAn antimicrobial and antibacterial. This compound contains an undetermined amount of epi-chlortetracycline
Brand nameAureomycin (Lederle).
General DescriptionChlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.
Purification MethodsPurify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]
Chlortetracycline hydrochloride Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Starch-->XANTHOPTERIN
Tag:Chlortetracycline hydrochloride(64-72-2) Related Product Information
Selenium dioxide 4-Dimethylaminobenzaldehyde 3-Dimethylaminopropylamine 4-Dimethylaminopyridine 4-Dimethylaminobenzoic acid Topotecan hydrochloride 1,4-Dioxane Chlortetracycline Clindamycin hydrochloride 5-Chlorosalicylaldehyde HEPTAMINOL HYDROCHLORIDE 4-Methyl-1-tetralone 1-Tetralone 1,2,3,4-Tetrahydro-1-naphthol FEMA 3377 isometheptene 3-(2-HYDROXY-2-PROPYL)PHENOL Difluorochloromethane