| Company Name: |
Beijing Ouhe Technology Co., Ltd
|
| Tel: |
010-82967028 13552068683 |
| Email: |
2355560935@qq.com |
| Products Intro: |
Product Name:Sorbic acid
CAS:22500-92-1
Purity:98% Package:10g;50g;100g;250g;500g
|
| Company Name: |
Nanjing chemical reagent co. LTD
|
| Tel: |
025-025-58369808 17895012682 |
| Email: |
1848231502@qq.com |
| Products Intro: |
Product Name:Sorbic acid
CAS:22500-92-1
Package:100g;500g;25kg
|
- Sorbic acid USP/EP/BP
-
- $1.10 / 1g
-
2021-07-23
- CAS:22500-92-1
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons min
|
| | Sorbic acid Basic information |
| | Sorbic acid Chemical Properties |
| solubility | Slightly soluble in water, freely soluble in ethanol (96 per cent). | | Odor | characteristic | | InChI | InChI=1S/C6H8O2/c1-2-3-4-5-6(7)8/h2-5H,1H3,(H,7,8)/b3-2+,5-4+ | | InChIKey | WSWCOQWTEOXDQX-MQQKCMAXSA-N | | SMILES | C(O)(=O)/C=C/C=C/C | | LogP | 1.268 (est) |
| | Sorbic acid Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. | | Chemical Properties | Sorbic acid is a tasteless, white to yellow-white crystalline powder
with a faint characteristic odor. | | Uses | Pharmaceutic aid (antimicrobial
agent). | | Definition | ChEBI: A hexadienoic acid with double bonds at C-2 and C-4; it has four geometrical isomers, of which the trans,trans-form is naturally occurring. | | Production Methods | Naturally occurring sorbic acid may be extracted as the lactone
(parasorbic acid) from the berries of the mountain ash Sorbus
aucuparia L. (Fam. Rosaceae). Synthetically, sorbic acid may be
prepared by the condensation of crotonaldehyde and ketene in the
presence of boron trifluoride; by the condensation of crotonaldehyde
and malonic acid in pyridine solution; or from 1,1,3,5-
tetraalkoxyhexane. Fermentation of sorbaldehyde or sorbitol with
bacteria in a culture medium has also been used. | | Pharmaceutical Applications | Sorbic acid is an antimicrobial preservative with antibacterial and
antifungal properties used in pharmaceuticals, foods, enteral
preparations, and cosmetics. Generally, it is used at concentrations
of 0.05–0.2% in oral and topical pharmaceutical formulations,
especially those containing nonionic surfactants. Sorbic acid is also
used with proteins, enzymes, gelatin, and vegetable gums. It has
been shown to be an effective preservative for promethazine
hydrochloride solutions in a concentration of 1 g/L.
Sorbic acid has limited stability and activity against bacteria and
is thus frequently used in combination with other antimicrobial
preservatives or glycols, when synergistic effects appear to occur. | | Safety | Sorbic acid is used as an antimicrobial preservative in oral and
topical pharmaceutical formulations and is generally regarded as a
nontoxic material. However, adverse reactions to sorbic acid and
potassium sorbate, including irritant skin reactions and
allergic hypersensitivity skin reactions (which are less frequent),
have been reported.
Other adverse reactions that have been reported include
exfoliative dermatitis due to ointments that contain sorbic
acid, and allergic conjunctivitis caused by contact lens solutions
preserved with sorbic acid.
No adverse reactions have been described after systemic
administration of sorbic acid, and it has been reported that it can
be ingested safely by patients who are allergic to sorbic acid.
However, perioral contact urticaria has been reported.
The WHO has set an estimated total acceptable daily intake for
sorbic acid, calcium sorbate, potassium sorbate, and sodium
sorbate, expressed as sorbic acid, at up to 25 mg/kg bodyweight.
Animal toxicological studies have shown no mammalian
carcinogenicity or teratogenicity for sorbic acid consumed at up
to 10% of the diet.
LD50 (mouse, IP): 2.82 g/kg
LD50 (mouse, oral): 3.20 g/kg
LD50 (mouse, SC): 2.82 g/kg
LD50 (rat, oral): 7.36 g/kg | | storage | Sorbic acid is sensitive to oxidation, particularly in the presence of
light; oxidation occurs more readily in aqueous solution than in the
solid form. Sorbic acid may be stabilized by phenolic antioxidants
such as 0.02% propyl gallate.
Sorbic acid is combustible when exposed to heat or flame. When
heated to decomposition, it emits acrid smoke and irritating fumes.
The bulk material should be stored in a well-closed container,
protected from light, at a temperature not exceeding 40℃. | | Incompatibilities | Sorbic acid is incompatible with bases, oxidizing agents, and
reducing agents. Some loss of antimicrobial activity occurs in the
presence of nonionic surfactants and plastics. Oxidation is
catalyzed by heavy-metal salts. Sorbic acid will also react with
sulfur-containing amino acids, although this can be prevented by
the addition of ascorbic acid, propyl gallate, or butylhydroxytoluene.
When stored in glass containers, the solution becomes very pH
sensitive; therefore, preparations using sorbic acid as a preservative
should be tested for their microbial purity after prolonged periods
of storage.
Aqueous solutions of sorbic acid without the addition of
antioxidants are rapidly decomposed when stored in polypropylene,
polyvinylchloride, and polyethylene containers. | | Regulatory Status | GRAS listed. Accepted as a food additive in Europe. Included in the
FDA Inactive Ingredients Database (ophthalmic solutions; oral
capsules, solutions, syrups, tablets; topical and vaginal preparations).
Included in nonparenteral medicines licensed in the UK.
Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
| | Sorbic acid Preparation Products And Raw materials |
|