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Postion:Product Catalog >Chemical Reagents>Organic reagents>The polycyclic compound> 2-Hydroxy-1-naphthaldehyde
2-Hydroxy-1-naphthaldehyde
  • 2-Hydroxy-1-naphthaldehyde
  • 2-Hydroxy-1-naphthaldehyde

2-Hydroxy-1-naphthaldehyde NEW

Price $5 $0.1
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-04-16

Product Details

Product Name: 2-Hydroxy-1-naphthaldehyde CAS No.: 708-06-5
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/04/16
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Name: Tina

 1. Materials information

Names

Name2-Hydroxy-1-naphthaldehyde
SynonymMore Synonyms

 2-Hydroxy-naphthaldehyde Biological Activity

DescriptionCFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].
Related Catalog
Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras
Target

KRAS(G12C)

In VitroCFL-137 (72 h)H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk  11.4, 24.2, 24.5, 12.3, 43.3, 44.5, 27.63, 32.4, 46.9, 26.2, 25.0, 10.8, 66.2 µM[1]。
In VivoCFL-137 (5 mg/kg，；15 mg/kg，；30 mg/kg，；i.p.)  H1792 (KRasG12C  LCLC-103H (KRasWT) 。 Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1] Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments Administration: I.p. Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 32.5%.
References

[1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.  

 Chemical & Physical Properties

Density1.3±0.1 g/cm3
Boiling Point305.8±0.0 °C at 760 mmHg
Melting Point82-85ºC
Molecular FormulaC11H8O2
Molecular Weight172.18
Flash Point134.3±13.0 °C
Exact Mass172.052429
PSA37.30000
LogP2.84
Vapour Pressure0.0±0.6 mmHg at 25°C
Index of Refraction1.719

 MSDS

2-Hydroxy-naphthaldehyde MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • QJ0300000

  • CHEMICAL NAME :

  • 1-Naphthaldehyde, 2-hydroxy-

  • CAS REGISTRY NUMBER :

  • 708-06-5

  • BEILSTEIN REFERENCE NO. :

  • 0742777

  • LAST UPDATED :

  • 199709

  • DATA ITEMS CITED :

  • 5

  • MOLECULAR FORMULA :

  • C11-H8-O2

  • MOLECULAR WEIGHT :

  • 172.19

  • WISWESSER LINE NOTATION :

  • T66J BVH CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 710 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

  • REFERENCE :

  • GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 1170 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

  • REFERENCE :

  • GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 7250 mg/kg/5D-I

  • TOXIC EFFECTS :

  • Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

  • REFERENCE :

  • GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 15 gm/kg/30D-I

  • TOXIC EFFECTS :

  • Kidney, Ureter, Bladder - urine volume decreased Blood - change in clotting factors Blood - changes in leukocyte (WBC) count

  • REFERENCE :

  • GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986

 Safety Information

SymbolArticle illustration Article illustration
GHS07, GHS09
Signal WordWarning
Hazard StatementsH315-H319-H335-H400
Precautionary StatementsP261-P273-P305 + P351 + P338
Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Gloves
Hazard CodesXi: Irritant;N: Dangerous for the environment;
Risk PhrasesR36/37/38
Safety PhrasesS24/25
RIDADRUN 3077 9
WGK Germany2
RTECSQJ0300000
HS Code2912499000

 Synthetic Route

Previous 1/15 Next
Article illustration

Chloroform

67-66-3

Article illustration

2-Naphthol

135-19-3

~77%

Article illustration

2-Hydroxy-napht...

708-06-5

Literature: Kalechits; Osinovskii; Matveenko; Ol'khovik Russian Journal of Applied Chemistry, 2002 , vol. 75, # 6 p. 962 - 964
Article illustration

1-Naphthaleneca...

5392-12-1

~92%

Article illustration

2-Hydroxy-napht...

708-06-5

Literature: Ranade, Anup A.; Joseph, Augustine R.; Kumbhar, Virendra B.; Paradkar, Madhusudan V. Journal of Chemical Research, Miniprint, 2003 , # 8 p. 857 - 868 Title/Abstract Full Text Show Details Ranade, Anup A.; Joseph, Augustine R.; Kumbhar, Virendra B.; Paradkar, Madhusudan V. Journal of Chemical Research, Miniprint, 2003 , # 11 p. 1175 - 1184
Article illustration

N,N-Dimethylfor...

68-12-2

Article illustration

2-Naphthol

135-19-3

~90%

Article illustration

2-Hydroxy-napht...

708-06-5

Literature: Moazzam Ali, Mir; Sana, Sariah; Tasneem; Rajanna; Saiprakash Synthetic Communications, 2002 , vol. 32, # 9 p. 1351 - 1356

 Precursor & DownStream

Precursor  10

Previous 1/3 Next

  • Article illustration CAS#:67-66-3
    Chloroform

  • Article illustration CAS#:135-19-3
    2-Naphthol

  • Article illustration CAS#:5392-12-1
    1-Naphthaleneca...

  • Article illustration CAS#:68-12-2
    N,N-Dimethylfor...

DownStream  10

Previous 1/3 Next

  • Article illustration CAS#:1084-35-1
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  • Article illustration CAS#:106910-71-8
    2-[(2-oxonaphth...

 Customs

HS Code2912499000
Summary2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles25

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Schiff bases attached L-glutamine and L-asparagine: first investigation on antimutagenic and antimicrobial analyses.

Artif. Cells. Nanomed. Biotechnol. 42(3) , 199-204, (2014)

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J. Clin. Invest. 124(6) , 2585-98, (2014)

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 Synonyms

2-Hydroxy-1-naphthaldehyde
2-hydroxynaphthalene-1-carboxaldehyde
1-naphthalenecarboxaldehyde, 2-hydroxy
1-Naphthalenecarboxaldehyde, 2-hydroxy-
EINECS 211-902-0
2-Hydroxy-naphthaldehyde
MFCD00004005
.β.-Hydroxy-.α.-naphthaldehyde


2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

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  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

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4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 13213167925

WhatsApp/Skype/Wechat/LINE: 86 13213167925



Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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