Chemical Safety Data Sheet MSDS / SDS

2,3-Butanedione

Revision Date:2024-03-16Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: 2,3-Butanedione
CBnumber: CB3853625
CAS: 431-03-8
EINECS Number: 207-069-8
Synonyms: 2,3-Butanedione,Diacetyl

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233 Keep container tightly closed.

P240 Ground/bond container and receiving equipment.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P264 Wash hands thoroughly after handling.

P264 Wash skin thouroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311 Call a POISON CENTER or doctor/physician.

P370+P378 In case of fire: Use … for extinction.

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/container to..…

Hazard statements

H225 Highly Flammable liquid and vapour

H302 Harmful if swallowed

H315 Causes skin irritation

H318 Causes serious eye damage

H319 Causes serious eye irritation

H331 Toxic if inhaled

H335 May cause respiratory irritation

SECTION 3: Composition/information on ingredients

Substance

Product name: 2,3-Butanedione
Synonyms: 2,3-Butanedione,Diacetyl
CAS: 431-03-8
EC number: 207-069-8
MF: C4H6O2
MW: 86.09

SECTION 4: First aid measures

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Carbon dioxide (CO2) Foam Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Advice for firefighters

No data available

Further information

No data available

NFPA 704

HEALTH	2	Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE	3	Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

For personal protection see section 8.

Environmental precautions

No data available

Methods and materials for containment and cleaning up

No data available

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Use with local exhaust ventilation. Advice on safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

No data available

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact Material: butyl-rubber

Minimum layer thickness: 0,7 mm

Break through time: 240 min Material tested:Butoject? (KCL 898)

Body Protection

Long sleeved clothing, Preventive skin protection

Control of environmental exposure

Prevent product from entering drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearance liquid
OdourStench.
Odour Threshold0,0086 ppm
pHNo data available
Melting point/freezing pointMelting point: -2 °C
Initial boiling point and boiling range 88 °C - lit.
Flash point7 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limits Upper explosion limit: 13,0 %(V) Lower explosion limit: 2,4 %(V)
Vapour pressure 229 hPa at 50 °C 69,6 hPa at 20 °C
Vapour density 3 (vs air)
Relative densityNo data available
Water solubility200 g/l at 25 °C
Partition coefficient: n-octanol/waterlog Pow: -1,34 - (Lit.), Bioaccumulation is not expected.
Autoignition temperature345 °C
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

No data available

Possibility of hazardous reactions

Violent reactions possible with:

alkalines Acids

Risk of ignition or formation of inflammable gases or vapours with: strong oxidising agents

Conditions to avoid

No data available

Incompatible materials

various plastics

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 1.580 mg/kg Remarks: (RTECS)
LC50 Inhalation - Rat - 4 h - 2,25 - 5,2 mg/l Remarks: (External MSDS)
Symptoms: Possible damages:, Irritation symptoms in the respiratory tract. LD50 Dermal - Rabbit - > 5.000 mg/kg
Remarks: (RTECS)

Skin corrosion/irritation

Skin - Rabbit Result: Irritations
Remarks: (External MSDS)

Serious eye damage/eye irritation

No data available

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

Test Type: Mutagenicity (mammal cell test): micronucleus.
Result: negative
Remarks: (National Toxicology Program)

Carcinogenicity

No data available

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

Inhalation - May cause damage to organs through prolonged or repeated exposure. - Respiratory system

Aspiration hazard

No data available

Toxicity

LD50 orally in rats: 1580 mg/kg (Jenner)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

LC50 - Leuciscus idus (Golden orfe) - 46 - 100 mg/l - 96 h Remarks: (External MSDS)

Toxicity to bacteria

Remarks: (Hommel)

(butanedione)

Persistence and degradability

Biodegradability Result: - Readily biodegradable.

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

Waste treatment methods

Product

No data available

SECTION 14: Transport information

UN number

ADR/RID: 2346 IMDG: 2346

UN proper shipping name

ADR/RID: BUTANEDIONE IMDG: BUTANEDIONE IATA: Butanedione

Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

Packaging group

ADR/RID: II IMDG: II IATA: II

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

EC Inventory:Listed.

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Irreversible obstructive lung disease has been documented among workers exposed in a variety of settings. These include 2,3-butanedione (diacetyl) production in the chemical industry, production of 2,3-butanedione (diacetyl)-containing flavorings, and production of diacetyl-containing, butter-flavored food products such as microwave popcorn. Many cases have been confirmed to have severe clinical bronchiolitis obliterans.Do NOT take working clothes home.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.