2,4-DIAMINOANISOLE

Acute toxicity - Category 4, Oral

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

H302 Harmful if swallowed

H341 Suspected of causing genetic defects

H350 May cause cancer

H411 Toxic to aquatic life with long lasting effects

P201 Obtain special instructions before use.

P273 Avoid release to the environment.

P281 Use personal protective equipment as required.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P203 Obtain, read and follow all safety instructions before use.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P273 Avoid release to the environment.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P318 IF exposed or concerned, get medical advice.

P391 Collect spillage.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Target Organs: Skin, thyroid, liver, reproductive system (NIOSH, 2016)

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Cover skin burns with dry sterile dressings after decontamination . /Organic bases/Amines and related compounds/

Powder, water spray, foam, carbon dioxide.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)

Use water spray, powder, foam, carbon dioxide.

Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into sealable containers. Do NOT let this chemical enter the environment.

Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into sealable containers. Do NOT let this chemical enter the environment.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants. Well closed.Separated from strong oxidants Well closed.

MAK: skin absorption (H); carcinogen category: 2

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear face shield or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

NIOSH considers 2,4-diaminoanisole (and its salts) to be a potential occupational carcinogen.

Decomposes on heating. This produces toxic fumes including nitrogen oxides. Reacts with strong oxidants.

no data available

2,4-DIAMINOANISOLE is incompatible with the following: Strong oxidizers (NIOSH, 2016).

no data available

Strong oxidizers.

The substance decomposes on heating producing toxic fumes including nitrogen oxides.

no data available

no data available

no data available

no data available

Evaluation: There is inadequate evidence in humans for the carcinogenicity of 2,4-diaminoanisole. There is sufficient evidence in experimental animals for the carcinogenicity of 2,4-diaminoanisole. Overall evaluation: 2,4-Diaminoanisole is possibly carcinogenic to humans (Group 2B). 2,4-Diaminoanisole and its salts

no data available

no data available

This substance is possibly carcinogenic to humans.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.

no data available

A range of BCF values of 1.3 to 4.6 were measured for carp exposed to 2 ppm 2,4-diaminoanisole over the course of a 6 week incubation period(1). According to a classification scheme(2), this BCF range suggests bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2,4-diaminoanisole can be estimated to be 53(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2,4-diaminoanisole is expected to have high mobility in soil. 2,4-Diaminoanisole is a weak base with an estimated pKa of 5.15(SRC), calculated by a method based on linear free energy relationships and perturbed molecular orbital theory(3). This estimated pKa indicates that 2,4-diaminoanisole will partially exist in the protonated form in acidic moist soils and cations generally adsorb to soils more strongly than their neutral counterparts(4). Moreover, anilines (aromatic amines) are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(5,6), suggesting that the mobility of 2,4-diaminoanisole may be much lower in some soils than indicated by the estimated Koc value(SRC).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3077 (For reference only, please check.)

IMDG: UN3077 (For reference only, please check.)

IATA: UN3077 (For reference only, please check.)

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

ADR/RID: 9 (For reference only, please check.)

IMDG: 9 (For reference only, please check.)

IATA: 9 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Do NOT take working clothes home.