Chemical Safety Data Sheet MSDS / SDS

p-Phenylenediamine

Revision Date:2024-05-18Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: p-Phenylenediamine
CBnumber: CB9852680
CAS: 106-50-3
EINECS Number: 203-404-7
Synonyms: p-phenylenediamine,benzene-1,4-diamine

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311 Call a POISON CENTER or doctor/physician.

P337+P313 IF eye irritation persists: Get medical advice/attention.

P405 Store locked up.

Hazard statements

H412 Harmful to aquatic life with long lasting effects

H410 Very toxic to aquatic life with long lasting effects

H400 Very toxic to aquatic life

H373 May cause damage to organs through prolonged or repeated exposure

H370 Causes damage to organs

H351 Suspected of causing cancer

H336 May cause drowsiness or dizziness

H335 May cause respiratory irritation

H331 Toxic if inhaled

H319 Causes serious eye irritation

H317 May cause an allergic skin reaction

H315 Causes skin irritation

H311 Toxic in contact with skin

H301 Toxic if swalloed

SECTION 3: Composition/information on ingredients

Substance

Product name: p-Phenylenediamine
Synonyms: p-phenylenediamine,benzene-1,4-diamine
CAS: 106-50-3
EC number: 203-404-7
MF: C6H8N2
MW: 108.14

SECTION 4: First aid measures

Description of first aid measures

General advice

First aider needs to protect himself. Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides, Nitrogen oxides (NOx) Combustible.

Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	3	Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE	0	Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Work under hood. Do not inhale substance/mixture. For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Appropriate engineering controls

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril? L

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril? L

Body Protection

protective clothing

Respiratory protection

required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains.

Exposure limits

TLV-TWA 0.1 mg/m³ (ACGIH 1989); TWA skin 0.1 mg/m³ (MSHA and OSHA); IDLH 25 mg/m³ (NIOSH); carcinogenicity: Animal Inadequate Evidence (IARC). .

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearance flakes
OdourNo data available
Odour ThresholdNo data available
pH9 at 50 g/l at 20 °C
Melting point/freezing pointMelting point/range: 138 - 143 °C - lit.
Initial boiling point and boiling range267 °C - lit.
Flash point110 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)The product is not flammable. - Flammability (solids)
Upper/lower flammability or explosive limitsLower explosion limit: 1,5 %(V)
Vapour pressure 1,44 hPa at 100 °C
Vapour density 3.7 (vs air)
Relative density0,726 g/cm3 at 22 °C
Water solubility31 g/l at 20 °C - OECD Test Guideline 105 - soluble
Partition coefficient: n-octanol/waterlog Pow: -0,839 at 21 °C
Autoignition temperatureNo data available
Decomposition temperatureNo data available
ViscosityNo data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

Surface tension 80 mN/m at 20 °C

SECTION 10: Stability and reactivity

Reactivity

Forms explosive mixtures with air on intense heating.

A range from approx. 15 Kelvin below the flash point is to be rated as critical.

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

No data available

Conditions to avoid

Strong heating.

Incompatible materials

acids, Acid chlorides, Acid anhydrides, Chloroformates, Strong oxidizing agents

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)

Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 80 mg/kg
LC50 Inhalation - Rat - male - 4 h - 0,92 mg/l (OECD Test Guideline 403)

Skin corrosion/irritation

Skin - Rabbit
Result: Mild skin irritation - 24 h

Serious eye damage/eye irritation

Eyes - Rabbit
Result: Irritating to eyes. (OECD Test Guideline 405)

Respiratory or skin sensitization

in vivo assay - Mouse
Result: May cause sensitization by skin contact. (OECD Test Guideline 429)

Germ cell mutagenicity

Rat Embryo
Morphological transformation.
Hamster ovary
Cytogenetic analysis OECD Test Guideline 474 Rat - male and female Result: negative

Carcinogenicity

This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification.
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Additional Information

Repeated dose toxicity - Rat - male and female - Oral - NOAEL (No observed adverse effect level) - 16 mg/kg
RTECS: SS8050000
Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Toxicity

LD50 in rats (mg/kg): 80 orally, 37 i.p. (Burnett)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

flow-through test LC50 - Oncorhynchus mykiss (rainbow trout) - 3,9 mg/l - 96 h

(OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

semi-static test EC50 - Daphnia magna (Water flea) - 0,33 mg/l - 48 h

(OECD Test Guideline 202)

Toxicity to algae

static test EC50 - Pseudokirchneriella subcapitata - 0,27 mg/l - 72 h (OECD Test Guideline 201)

Toxicity to bacteria

Respiration inhibition EC50 - Sludge Treatment - 13,4 mg/l - 3 h (OECD Test Guideline 209)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 30 % - Not readily biodegradable. (OECD Test Guideline 301D)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Biological effects:

Forms toxic mixtures in water, dilution measures notwithstanding. Further information on ecology

Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

Waste treatment methods

Incompatibilities

Dust may form explosive mixture with air. A strong reducing agent. Incompatible with oxidizers; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides; and strong bases. Incompatible with organic anhydrides; isocyanates, aldehydes. Heat and light contribute to instability. Keep away from metals.

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Waste Disposal

Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal device.

SECTION 14: Transport information

UN number

ADR/RID: 1673 IMDG: 1673 IATA: 1673

UN proper shipping name

	ADR/RID: PHENYLENEDIAMINES IMDG: PHENYLENEDIAMINES
IATA: Phenylenediamines
14.3	Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1	IATA: 6.1
14.4	Packaging group ADR/RID: III IMDG: III	IATA: III
14.5	Environmental hazards ADR/RID: yes IMDG Marine pollutant: yes	IATA: no
14.6	Special precautions for user No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

EC Inventory:Listed.

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.The relation between odour and the occupational exposure limit cannot be indicated.Rinse contaminated clothing with plenty of water because of fire hazard.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.