Propoxur

Acute toxicity - Category 3, Oral

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H311 Toxic in contact with skin

H410 Very toxic to aquatic life with long lasting effects

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P391 Collect spillage.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Half-upright position. Refer for medical attention. See Notes.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention . See Notes.

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Miosis, blurred vision; sweating, salivation; abdominal cramps, nausea, diarrhea, vomiting; headache, lassitude (weakness, exhaustion), muscle twitching Target Organs: central nervous system, liver, kidneys, gastrointestinal tract, blood cholinesterase (NIOSH, 2016)

Container identification is important to determine appropriate therapeutic measures, since the vehicle (eg, hydrocarbon, methanol) may be as toxic as the insecticide. ...

Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full facepieces and are operated in a pressure-demand or other positive-pressure mode.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)

Use water spray, foam, powder, carbon dioxide.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after cleanup is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Keep in a well-ventilated room.Store in original container, preferably in locked area, away from children, food, feed.

TLV: 0.5 mg/m3, as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued.MAK: (inhalable fraction): 2 mg/m3; peak limitation category: II(8)

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety spectacles or eye protection in combination with breathing protection if powder.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

Decomposes on heating and on burning. This produces toxic fumes including methyl isocyanate and nitrogen oxides.

Hydrolized by strong alkali; 50% loss @ 20 deg C in 40 min @ pH 10

PROPOXUR is incompatible with the following: Strong oxidizers, alkalis [Note: Emits highly toxic methyl isocyanate fumes when heated to decomposition.] (NIOSH, 2016).

no data available

Believed compatible with most insecticides, fungicides, except alkalines.

When heated to decomposition it emits toxic fumes of /nitrogen oxide/.

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Cancer Classification: Group B2 Probable Human Carcinogen

No information is available on the reproductive or developmental effects of propoxur in humans. No adverse reproductive or developmental effects were observed in an oral study of rabbits exposed to propoxur. In a few studies of rats orally exposed to propoxur, fetotoxic effects, decreased numbers of pups, and depressed fetal weight have been reported.

The substance may cause effects on the nervous system by a cholinesterase inhibiting effect. This may result in convulsions and respiratory depression. Exposure could cause death.

Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. Tumours have been detected in experimental animals but may not be relevant to humans.

A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered.

AEROBIC: The primary mode of biodegradation for propoxur appears to be hydrolysis of the carbamate linkage(1). The biodegradation of propoxur under aerobic conditions in silt loam and sandy loam soils followed first order kinetics for the first 112 and 180 days, respectively(1). The half-life values were 80 days for the silt loam and 210 days for the sandy loam(1). Propoxur was the major extractable residue found in the studies(1). One day after propoxur was applied to a sandy loam soil with no history of insecticidal treatment, 94% remained(2). However, when soil was previously treated four times with carbofuran (a methylcarbamate), only 20% of the propoxur remained after 1 day; this shows that acclimation markedly affects the rate of biodegradation of propoxur in soil(2). In another laboratory study, the biodegradation half-life of propoxur in Montardon soil, not previously treated with carbofuran, was 146 days, while in previously treated soil, the half-life was 9.3 days(3). Propoxur is reported to biodegrade quite rapidly in water, particularly when the bacterial activity and temperature are high(4). In a biodegradation test which used a combination of activated sludge, silt loam soil, and sediment as an inoculum, the half-life of propoxur was 44 days under aerobic conditions(5). When glucose and peptone was added as a source of carbon and energy, the half-life decreased to 19 days under aerobic conditions(5). Using a mixture of non-acclimated sludge, field soil, and river sediment as inoculum, the aerobic biodegradation half-life was 0.6 day at an initial concentration of 2 ppm at 18-22 deg C(6).

An estimated BCF of 5 was calculated in fish for propoxur(SRC), using log Kow of 1.52(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of propoxur ranges from <1 to 103(1,2). In batch equilibrium studies, propoxur was very mobile, with Koc values of 3.4, 11.2, and 102.6 for sandy loam, silt loam, and silty clay soils, respectively(2). In other studies, Koc values ranged from 28-68, and for silt loam, sandy loam, sand, and clay loam soils, the Koc values were 39 (Kd = 0.597, 2.9 %OM, pH 5.9), 0.76 (Kd = 0.004, 1.1 %OM, pH 6.6), 34 (Kd = 0.181, 1.0 %OM, pH 4.3), and 28 (Kd = 0.329, 2.2 %OM, pH 6.4), respectively(1). According to a classification scheme(3), these Koc values suggest that propoxur has very high to high mobility in soil(SRC). In soil thin-layer mobility studies on six soils, propoxur was found to be mobile, with Rf values of 0.70 to 0.89(2).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2811 (For reference only, please check.)

IMDG: UN2811 (For reference only, please check.)

IATA: UN2811 (For reference only, please check.)

ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IMDG: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IATA: TOXIC SOLID, ORGANIC, N.O.S. (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Decomposition of compound starts at 220°C.Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.If the substance is formulated with solvents also consult the ICSCs of these materials.Carrier solvents used in commercial formulations may change physical and toxicological properties.