1-Phenyl-1,2-ethanediol synthesis
- Product Name:1-Phenyl-1,2-ethanediol
- CAS Number:93-56-1
- Molecular formula:C8H10O2
- Molecular Weight:138.16
15206-55-0
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93-56-1
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Yield:93-56-1 91%
Reaction Conditions:
with carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II);hydrogen;sodium t-butanolate in methanol at 80; under 37503.8 Torr; for 12 h;Glovebox;Autoclave;chemoselective reaction;Reagent/catalyst;Temperature;Pressure;Concentration;
Steps:
Typical procedures for the catalytic hydrogenation of α-keto esters
General procedure: A glass liner containing a stir bar was charged with substrate (0.5 mmol), base (0.05mmol), Ru-MACHO (5 umol) and MeOH (0.5 mL) in a glove box. The glass linerwas then placed into an autoclave followed by degassing with H2 three times. Thehydrogenation was carried out at 10-50 bar H2 with stirring at 25oC or 80oC for 12-24h. After the reaction finished, the autoclave was allowed to cool down to r.t. Thehydrogen gas was then carefully released in a fume hood, and the solution transferredto a flask with H2O (2 ml), extracted with EA (3x5 ml), dried with Na2SO4 andconcentrated in vacuo to afford the pure product 2a-2s or 3a-3s.
References:
Gao, Shaochan;Tang, Weijun;Zhang, Minghui;Wang, Chao;Xiao, Jianliang [Synlett,2016,vol. 27,# 11,art. no. ST-2016-W0067-L,p. 1748 - 1752] Location in patent:supporting information
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93-56-1
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