1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID
- CAS Number:46006-36-4
- Molecular formula:C8H6N2O2
- Molecular Weight:162.15
122-51-0
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$10.00/5ml
603-81-6
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$7.00/250mg
46006-36-4
139 suppliers
$19.00/250mg
Yield: 98%
Reaction Conditions:
at 130;
Steps:
5.1.92.A
A. lH-Benzo[d]imidazole-4-carboxyIic acid.; 2,3-Diaminobenzoic acid (1.0 g, 6.57 mmol) was suspended in triethylorthoformate (20 mL) and heated to 130 0C overnight. Diethyl ether (100 mL) was then added and the resulting precipitate filtered to give a white solid (1.04 g, 6.41 mmol, 98%). 1H NMR (400 MHz, DMSO-rf6) δ 8.22 (s, IH), 7.91 (dd, J = S.0, 1.2, IH), 7.82 (dd, J = 8.0, 1.2, IH), 7.29 (dd, J = 8.0, 7.6, IH); MS (ESI) m/z 163.0 [M+ 1]+.
References:
SIGNAL PHARMACEUTICALS, LLC WO2008/51494, 2008, A1 Location in patent:Page/Page column 132
64-18-6
1057 suppliers
$22.12/250ML
603-81-6
184 suppliers
$7.00/250mg
46006-36-4
139 suppliers
$19.00/250mg
64-18-6
1057 suppliers
$22.12/250ML
46006-36-4
139 suppliers
$19.00/250mg
603-81-6
184 suppliers
$7.00/250mg
208772-23-0
55 suppliers
$45.00/10mg
46006-36-4
139 suppliers
$19.00/250mg
606-18-8
295 suppliers
$9.00/1g
46006-36-4
139 suppliers
$19.00/250mg