(1H-PYRAZOL-4-YL)METHANOL synthesis
- Product Name:(1H-PYRAZOL-4-YL)METHANOL
- CAS Number:25222-43-9
- Molecular formula:C4H6N2O
- Molecular Weight:98.1
51105-90-9
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25222-43-9
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Yield: 75.78%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 4 h;
Steps:
19.2 Step-2: Preparation of (lH-Pyrazo-4-yI)-methanol:
To the stirred solution of methyl 1H- pyrazole-4-carboxylate 19-2 ( 19 g, 150.66 mmol) in THF (500 mL) was added lithium aluminium hydriede (8.58 g, 225.99 mmol) portionwise at 0°C. The reaction mixture was stirred at room temperature for 4 hours and then cooled to room temperature and quenched by Fieser workup. The organic later was filtered through celite and concentrated under reduced pressure to afford 1H- pyrazol-4-ylmethanol 19-3 ( 1 1.2 g, 114.17 mmol, 75.78% yield) as white solid. LC MS: ES+ 99 0
References:
C4 THERAPEUTICS, INC.;VEITS, Gesine, Kerstin;HE, Minsheng;HENDERSON, James, A.;NASVESCHUK, Christopher, G.;PHILLIPS, Andrew, J.;GOOD, Andrew, Charles WO2019/191112, 2019, A1 Location in patent:Page/Page column 318
37622-90-5
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25222-43-9
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$12.00/100mg
70817-17-3
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25222-43-9
104 suppliers
$12.00/100mg