2-(2-aminoethoxy)-1,1-dimethoxyethane synthesis
- Product Name:2-(2-aminoethoxy)-1,1-dimethoxyethane
- CAS Number:1228258-40-9
- Molecular formula:C6H15NO3
- Molecular Weight:149.19
97-97-2
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Yield:1228258-40-9 55%
Reaction Conditions:
Stage #1: ethanolaminewith sodium t-butanolate at 80 - 90; for 3 h;
Stage #2: chloroacetaldehyde dimethyl acetal at 90; for 3 h;
Steps:
1-3 Example 2
Add 29.5g ethanolamine and 31g sodium tert-butoxide into a 500mL three-necked flask, stir, heat to 80-90, stir and react for 3h, add dropwise 10g 2-chloroacetaldehyde dimethylacetal, and react at 90 for 3h,The GC control detection reaction is over.Post-treatment: add 1L ice water, then add 1L dichloromethane, stir for 30min, stand for liquid separation, wash the organic phase with 50ml sodium sulfate solution, separate the liquid, concentrate the organic phase, and distill with oil pump.Get 6.6g product, namely (2,-(2-aminoethoxy)-1,1-dimethoxyethane,The yield was 55%.
References:
CN113527119,2021,A Location in patent:Paragraph 0031-0039
1228258-29-4
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1228258-40-9
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