ChemicalBook CAS DataBase List 2-BROMO-5-CHLORO-3-NITROPYRIDINE

2-BROMO-5-CHLORO-3-NITROPYRIDINE synthesis

3synthesis methods

Product Name:2-BROMO-5-CHLORO-3-NITROPYRIDINE
CAS Number:75806-86-9
Molecular formula:C5H2BrClN2O2
Molecular Weight:237.44

5409-39-2 Synthesis

5409-39-2
225 suppliers
$6.00/250mg

75806-86-9
158 suppliers
$14.00/1g

Yield:75806-86-9 73%

Reaction Conditions:

with hydrogen bromide;bromine;sodium nitrite in water at 0 - 20; for 1 h;

Steps:

Intermediate 32b: 2-Bromo-5-chloro-3-nitropyridine
To a solution of intermediate 32a (10.0 g, 57.6 mmol) in HBr [(31 .0 mL (100%), 286.4 mmol)] at 0 00 sodium nitrite (13.8 g, 199.9 mmol) was added drop wise. To the stirred solution Br2 (10.0 mL, 197.1 mmol) was added in water and stirred at room temperature for 1 h. The reaction mixture was basified with NaHCO3 solution (pH=7) and extracted with ethyl acetate, washed with water, and dried over anhydrousNa2SO4 The solvent was removed under vacuo to yield the title product (10.0 g,73.0%) as a yellow solid.

References:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH;MADANAHALLI RANGANATH RAO, Jagannath;GURRAM RANGA, Madhavan;PACHIYAPPAN, Shanmugam WO2014/202580, 2014, A1 Location in patent:Page/Page column 100

FullText

1072-98-6
696 suppliers
$5.00/1g

75806-86-9
158 suppliers
$14.00/1g

References

21427-61-2 Synthesis

21427-61-2
182 suppliers
$6.00/1g

75806-86-9
158 suppliers
$14.00/1g

References

2-BROMO-5-CHLORO-3-NITROPYRIDINE Related Search:

2-BROMO-3-CHLORO-5-NITROPYRIDINE 3-AMINO-2-BROMO-5-CHLOROPYRIDINE 2-Chloro-3-bromo-5-nitropyridine 2-Bromo-5-methylpyridine 2-Bromo-4-methylpyridine 2-Bromo-4-nitroimidazole 2-Bromo-4-fluoropyridine 2-Bromo-5,6-diphenylpyrazine 2-Bromo-4-chloropyridine 2-Bromopyridine-4-carboxylic acid