ChemicalBook CAS DataBase List 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID

2-CHLOROQUINOLINE-4-CARBOXYLIC ACID synthesis

7synthesis methods

Product Name:2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
CAS Number:5467-57-2
Molecular formula:C10H6ClNO2
Molecular Weight:207.61

15733-89-8
272 suppliers
$14.14/1gm:

5467-57-2
140 suppliers
$6.00/250mg

Yield: 87.5%

Reaction Conditions:

with trichlorophosphate for 1 h;Reflux;

Steps:

16.b
b) The product of the previous step (10.2 g, 53.9 mmol) was dissolved in 20 mL of phosphorus oxychloride and refluxed for 1 h. The phosphorus oxychloride was removed by rotary evaporation, the residue was poured into ice water, the pH was adjusted to 4-5 with a saturated aqueous solution of sodium bicarbonate, suction filtered, washed with water and dried to obtain 9.8 g of 2-chloroquinoline-4-carboxylic acid, the yield was 87.5%;

References:

China Pharmaceutical University;Xu Jinyi;Li Wenlong;Xu Shengtao;Xu Feijie;Shuai Wen;Sun Honghao;Zhu Zheying;Yao Hong CN109467549, 2019, A Location in patent:Paragraph 0027; 0100; 0104

15733-89-8
272 suppliers
$14.14/1gm:

5467-57-2
140 suppliers
$6.00/250mg

References