ChemicalBook CAS DataBase List 3-Bromonitrobenzene

3-Bromonitrobenzene synthesis

12synthesis methods

Product Name:3-Bromonitrobenzene
CAS Number:585-79-5
Molecular formula:C6H4BrNO2
Molecular Weight:202.01

13331-27-6 Synthesis

13331-27-6
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$5.00/1g

585-79-5
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$15.00/1g

Yield:585-79-5 80%

Reaction Conditions:

with tetrabutylammomium bromide;copper(ll) bromide in water at 100;Sealed tube;

Steps:

1. Preparation of aryl bromides
General procedure: To a stirred solution of arylboronic acids 1 (1 mmol), CuBr₂ (335 mg, 1.5 mmol), TBAB (33 mg, 0.1 mmol) water (5mL) in a sealed tube for 5-12 h at 100 °C. After completion of the reaction as indicated by TLC, the mixture was extracted with EtOAc (2×5 mL). The organic layer was dried by anhydrous Na₂SO₄, concentrated in vacuo, and the residue was isolated by simply column chromatography (PE/EA 40:1-20:1) to afford products, respectively.

References:

Tang, Yan-Ling;Xia, Xian-Song;Gao, Jin-Chun;Li, Min-Xin;Mao, Ze-Wei [Tetrahedron Letters,2021,vol. 64,art. no. 152738] Location in patent:supporting information

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99-09-2 Synthesis