3-Fluoropropiophenone synthesis
- Product Name:3-Fluoropropiophenone
- CAS Number:455-67-4
- Molecular formula:C9H9FO
- Molecular Weight:152.17
701-38-2
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$45.00/1g
455-67-4
201 suppliers
$6.00/1g
Yield:-
Reaction Conditions:
with Jones reagent in acetone at 0 - 10; for 3 h;
Steps:
2
Example 2Preparation of 3-fluoropropiophenone350 ml of Jones reagent was added dropwise to 100 g of 1-(3-fluorophenyl)propan-1-ol in 1 L of acetone at 0 to 10° C., over a period of two hours. The reaction solution was stirred at 0 to 10° C. for additional 1 hour. The solvent was removed in vacuo. The reaction solution was extracted with 400 ml of DCM and organic layer was dried over sodium sulfate. The solvent was removed in vacuo. After drying, 120 g of 3-fluoropropiophenone were obtained as a yellow oil and taken as such to the next step 1H NMR (CDCl3): δ=1.3 (t, 3H, -CH2-CH3, 2.95 (q, 2H, CO-CH2-CH3), 7.25 (m, 1H, Ar 5-H), 7.43 (m, 1H, Ar-4H), 7.63 (q, 1H, Ar-6H), 7.75 (bd, 1H, Ar-4H)
References:
US2008/221358,2008,A1 Location in patent:Page/Page column 4
28593-12-6
31 suppliers
$310.00/1g
455-67-4
201 suppliers
$6.00/1g