4-Bromo-4'-methoxybiphenyl synthesis
- Product Name:4-Bromo-4'-methoxybiphenyl
- CAS Number:58743-83-2
- Molecular formula:C13H11BrO
- Molecular Weight:263.13
Yield:58743-83-2 99%
Reaction Conditions:
with caesium carbonate in water;N,N-dimethyl-formamide at 20;Inert atmosphere;Suzuki Coupling;
Steps:
General procedure for Suzuki cross coupling reaction
General procedure: The Suzuki coupling reactions were carried out in a test tube (13 mm) using an organic synthesizer. Aryl iodides, bromides and chlorides (0.1 mmol) base (150 mol%), arylboronic acid (0.15 mmol) and Pd catalysts 3-5 atom% were placed in a test tube. The argon gas was supplied from the balloon with argon exchange 2 times without degassing. Solvent was added and stirred at 1000 rpm at specified temperature for the desired time. Completion of the reaction was monitored by TLC. After completion, the reaction was cooled and quenched by 1M HCl, extract with EtOAc. The organic layer was evaporated, dried and the yields were reported as NMR or isolated yield after purification by silica gel column chromatography (eluted with EtOAc/Hexane). The products were confirmed by 1H NMR spectra and mass comparing with the pure, commercially available compounds and reported NMR in the literature which exactly matched with the reported values.1-18
References:
Karanjit, Sangita;Kashihara, Masaya;Nakayama, Atsushi;Shrestha, Lok Kumar;Ariga, Katsuhiko;Namba, Kosuke [Tetrahedron,2018,vol. 74,# 9,p. 948 - 954] Location in patent:supporting information
4482-01-3
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58743-83-2
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