(S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido synthesis
- Product Name:(S)-Methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido
- CAS Number:781664-81-1
- Molecular formula:C44H45N5O3
- Molecular Weight:691.86
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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Yield: 76%
Reaction Conditions:
with potassium phosphate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran for 96 h;Product distribution / selectivity;Heating / reflux;
Steps:
18
A mixture of methyl N-[4-(5,5-dimethyl-[1 ,3,2]dioxaborinan-2-yl)phenyl-4-yl- methyl]-N-pentanoyl-L-valinate (2 g), 5-(2-Bromophenyl)-1-triphenylmethyl- 1 H-tetrazole (2.24 g) and anhydrous K3PO4 (3.11 g) in anhydrous tetrahydrofuran (33 ml_) was degassed by vacuum/nitrogen purges (3 x). Then, dichloro[1 ,1'-bis(diphenylphosphino)ferrocene]palladium (II) (117 mg) was added, the mixture was degassed by vacuum/nitrogen purges (3 x) and heated at reflux for 4 days. The reaction mixture was cooled, passed through a pad of celite and the filtrate evaporated under vacuum. The residue was chromatographed on silica (eluant: cyclohexane /ethyl acetate 9:1 ) to give methyl N-pentanoyl-N-[{2'-[1-(triphenylmethyl)-1 H-tetrazol-5-yl]-1 ,1'-biphenyl- 4-yl}methyl]-L-valinate (2.53 g, 76% yield).
References:
ENANTIA, S. L. WO2006/67216, 2006, A2 Location in patent:Page/Page column 22
638-29-9
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781664-81-1
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1000210-73-0
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638-29-9
261 suppliers
$14.14/1gm:
781664-81-1
13 suppliers
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143945-72-6
44 suppliers
$75.00/50 mg
781664-81-1
13 suppliers
$466.51/1g