Benzoyl chloride, 2-chloro-4-(methylsulfonyl)- synthesis
- Product Name:Benzoyl chloride, 2-chloro-4-(methylsulfonyl)-
- CAS Number:106904-10-3
- Molecular formula:C8H6Cl2O3S
- Molecular Weight:253.1
53250-83-2
235 suppliers
$13.00/1g
106904-10-3
17 suppliers
$65.00/50mg
Yield:106904-10-3 97%
Reaction Conditions:
with dichlorosulfoxide;N,N-dimethyl-formamide in toluene at 0 - 50; for 27 h;
Steps:
1.5 5. 4- (methylsulfonyl) -2-chlorobenzoyl chlorideSynthesis
Four-necked flask add the compound 4- (methylsulfonyl) -2-chloro-benzoic acid 100g (0.426mol), toluene was added 500mL (not all dissolved at room temperature), add with stirring a catalytic amount of dimethylformamide 2mL. Installing a gas absorption device, was cooled to 0 deg.] C, slowly dropwise thionyl chloride 100g (0.84mol), was added dropwise need 3h, during the addition to maintain the temperature below 5 . After the dropwise addition, heated slowly to 50 (mixture was gradually clarified, and finally clear solution is formed), the reaction 24h, TLC detection reaction process (developing solvent: ethyl acetate). Rotary evaporation to remove the solvent and excess thionyl chloride to give a residue 105g, a yield of 97%, without further purification, was used directly in the next reaction.
References:
CN105693569,2016,A Location in patent:Paragraph 0054; 0055; 0056
288-88-0
780 suppliers
$10.00/5g
53250-83-2
235 suppliers
$13.00/1g
504-02-9
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$5.00/10g
106904-10-3
17 suppliers
$65.00/50mg
1671-18-7
72 suppliers
$51.00/10mg
106904-10-3
17 suppliers
$65.00/50mg