ChemicalBook CAS DataBase List BOC-4-ABZ-OH

BOC-4-ABZ-OH synthesis

12synthesis methods

Product Name:BOC-4-ABZ-OH
CAS Number:66493-39-8
Molecular formula:C12H15NO4
Molecular Weight:237.25

ETHYL 4-(TERT-BUTOXYCARBONYLAMINO)BENZOATE

110969-44-3
17 suppliers
$333.00/5g

66493-39-8
158 suppliers
$10.00/1g

Yield:66493-39-8 74.5%

Reaction Conditions:

with water;sodium hydroxide in methanol at 25;

Steps:

Synthesis of compound 9
A mixture of compound 8 (300mg, 1.l3mmol) and NaOH (1M, 7mL) in MeOH (5 mL) was stirred at room temperature for overnight. After concentrated, the residue was dissolved in H20, 1 N HC1 was added until pH=2, and the mixture was extracted with EA. The organic layer was washed with brine, dried over Na2SO4 and concentrated to provide the product compound 9(200mg, yield: 74.5%). It was used for the next step without further purification. ‘H NIVIR (DMSO-d6, 400MHz): 12.64 (s, 1H), 9.77 (s, 1H), 7.89(d, 2H, J = 8.4Hz), 7.61 (d, 2H, J = 8.8Hz), 1.54 (s, 9H).

References:

SUZHOU KINTOR PHARMACEUTICALS, INC.;GUO, Chuangxin;TONG, Youzhi WO2017/219800, 2017, A1 Location in patent:Paragraph 00131; 00132

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