ChemicalBook CAS DataBase List ditetradecylamine

ditetradecylamine synthesis

9synthesis methods

Product Name:ditetradecylamine
CAS Number:17361-44-3
Molecular formula:C28H59N
Molecular Weight:409.77

2016-42-4
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112-71-0 Synthesis

112-71-0
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17361-44-3
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Yield:17361-44-3 32%

Reaction Conditions:

with potassium carbonate in dimethyl sulfoxide at 80; for 12 h;

Steps:

5.3.1.1. Synthesis of N,N-di-n-hexylamine (i)a

General procedure: Mixture of n-hexylamine (2 g, 19.6 mmol), n-hexyl bromide (3.17 g, 19.6 mmol) and anhydrous potassium carbonate (1.99 g, 19.6 mmol) in 15 mL dimethyl sulfoxide was kept under stirring for 12 h at 80^oC. The reaction mixture was taken in 50 mL chloroform, washed with water (3 x 50 mL), dried over anhydrous magnesium sulfate and filtered. Chloroform was removed from the filtrate on a rotary evaporator. Silica gel column chromatographic purification of the resulting residue using 60-120 mesh silica gel size and 1-2% methanol in chloroform (v/v) as the eluent, afforded the intermediate secondary amine. This yielded compound (i)a as a Yellow liquid (1.2 g, 32% yield, Rf =0.6 in 10% methanolic chloroform, v/v,as the TLC developing solvent).

References:

Sudhakar, Godeshala;Bathula, Surendar Reddy;Banerjee, Rajkumar [European Journal of Medicinal Chemistry,2014,vol. 86,p. 653 - 663]

2016-42-4
202 suppliers
$25.00/5g

112-64-1 Synthesis