ChemicalBook CAS DataBase List Ethyl 3-aminopropanoate hydrochloride

Ethyl 3-aminopropanoate hydrochloride synthesis

7synthesis methods

Product Name:Ethyl 3-aminopropanoate hydrochloride
CAS Number:4244-84-2
Molecular formula:C5H12ClNO2
Molecular Weight:153.61

64-17-5 Synthesis

64-17-5
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107-95-9
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4244-84-2
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$5.00/1g

Yield:4244-84-2 87%

Reaction Conditions:

with thionyl chloride at -10; for 2 h;Reflux;

Steps:

β-Alanine ethyl ester hydrochloride.
Freshly distilled thionyl chloride (250 mL) was added drop-wise to stirring absolute EtOH (400 mL) at -10 ºC. After 20 min at -10 ºC, β-alanine (82.56 g, 0.93 mol) was slowly added to the thionyl chloride/EtOH solution. This mixture was refluxed for 2 h. Excess thionyl chloride was distilled off and the volume of the solution was reduced by half under vacuum. The white precipitate that crystallized from the reduced solution was filtered and washed with cold diethylether to give β-alanine ethyl ester hydrochloride as a white crystalline powder (124.34 g, 87%).

References:

Liao, Vivian;Liu, Tao;Codd, Rachel [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 19,p. 6200 - 6204] Location in patent:supporting information

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