GSK 2830371 synthesis
- Product Name:GSK 2830371
- CAS Number:1404456-53-6
- Molecular formula:C23H29ClN4O2S
- Molecular Weight:461.02
21427-62-3
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$6.00/1g
1404456-53-6
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$25.00/1mg
Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 3.83 h / 20 °C / Inert atmosphere
1.2: 12.5 h / Reflux
1.3: pH 9
2.1: tin(II) chloride dihdyrate / ethyl acetate / 3 h / 85 °C / Inert atmosphere
3.1: methanol / 2 h / 50 °C / Inert atmosphere
4.1: sodium cyanoborohydride / methanol / 14 h / 0 - 20 °C / Inert atmosphere
4.2: pH 4
5.1: N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C
5.2: 20 °C
References:
GLAXOSMITHKLINE LLC;BOBKO, Mark, A.;DARCY, Michael, G.;EVANS, Karen, A.;FAITG, Thomas, H.;KAURA, Arun, Chandar;PENG, Xin;SARPONG, Martha, A.;SEEFELD, Mark, A.;SU, Dai-shi WO2012/149102, 2012, A1
1404457-07-3
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inquiry
1404456-53-6
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1211533-93-5
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$10.00/100mg
1404456-53-6
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89639-36-1
57 suppliers
$65.00/100mg
1404456-53-6
105 suppliers
$25.00/1mg