Isobutylparaben synthesis

Yield:4247-02-3 87.6%

Reaction Conditions:

with [HBth]H₂PW₁₂O₄₀ at 108; for 5 h;Green chemistry;

Steps:

Synthesis of paraben compounds 2a-2h (general procedure).
General procedure: A mixture of p-hydroxybenzoic acid (10 mmol), alcohol 1a-1g, and IL1 or IL2 was refluxed until completion of the reaction (by TLC). The alcohol was evaporated, and the residue was extracted with ethyl acetate (3 × 10 mL). The organic phases were combined, dried, and concentrated. The precipitate was recrystallized from methanol to obtain the target product.

References:

Liu, B.;Liu, Y.;Sun, J.;Yin, D. [Russian Journal of Organic Chemistry,2020,vol. 56,# 8,p. 1476 - 1483][Zh. Org. Khim.,2020,vol. 56,# 8,p. 1476 - 1483,8]

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