ChemicalBook CAS DataBase List Methyl 2-aminonicotinate

Methyl 2-aminonicotinate synthesis

5synthesis methods

Product Name:Methyl 2-aminonicotinate
CAS Number:14667-47-1
Molecular formula:C7H8N2O2
Molecular Weight:152.15

67-56-1 Synthesis

67-56-1
733 suppliers
$9.00/25ml

5345-47-1 Synthesis

5345-47-1
370 suppliers
$9.00/1g

14667-47-1
202 suppliers
$6.00/1g

Yield:14667-47-1 93%

Reaction Conditions:

with sulfuric acid at 0 - 60; under 760.051 Torr; for 1.5 h;Inert atmosphere;Microwave irradiation;

Steps:

Methyl 2-aminonicotinate (21)

Concentrated sulfuric acid (96%, 144 mL, 2.69 mol, 18.6 equiv) was added dropwise to a stirred suspension of 5 (20.0 g, 0.145 mol) in MeOH (228 mL, 7.12 mol, 49.2 equiv) maintained at 0 C. The mixture was irradiated at atmospheric pressure under microwaves (power input 300 W) at 60 C for 1.5 h. The light brown mixture was poured onto iced water, maintained at 0 C and carefully quenched by adding solid Na2CO3 portionwise until complete neutralization (pH>8). The aqueous layer was extracted three times with AcOEt. The combined organic layers were washed with brine and water and dried over MgSO4. Evaporation of the organic layer yielded the title compound 21 in analytically pure form (21.15 g, 93%) as colourless needles

References:

Hédou, Damien;Deau, Emmanuel;Harari, Marine;Sanselme, Morgane;Fruit, Corinne;Besson, Thierry [Tetrahedron,2014,vol. 70,# 35,p. 5541 - 5549]

5345-47-1 Synthesis

5345-47-1
370 suppliers
$9.00/1g