ChemicalBook CAS DataBase List METHYL 3-AMINOBENZOATE

METHYL 3-AMINOBENZOATE synthesis

10synthesis methods

Product Name:METHYL 3-AMINOBENZOATE
CAS Number:4518-10-9
Molecular formula:C8H9NO2
Molecular Weight:151.16

67-56-1 Synthesis

67-56-1
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99-05-8
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$14.00/5g

4518-10-9
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$12.80/1g

Yield:4518-10-9 100%

Reaction Conditions:

with thionyl chloride at 0; for 24 h;Reflux;

Steps:

1 6.2.1 General procedure for the synthesis of methyl aminobenzoates 39b-42b
General procedure: A solution of the appropriate 2-aminobenzoic acid (1equiv) in MeOH was cooled to 0°C followed by a dropwise addition of thionyl chloride (2.5equiv). The mixture was refluxed for 24h. After evaporation of the solvent and neutralization by addition of a saturated aqueous NaHCO₃ solution, the mixture was extracted with EtOAc and the combined organic layers were dried over MgSO₄. Purification by CC (n-hexane/EtOAc) provided the title compounds.

References:

Hinsberger, Stefan;De Jong, Johannes C.;Groh, Matthias;Haupenthal, Jörg;Hartmann, Rolf W. [European Journal of Medicinal Chemistry,2014,vol. 76,p. 343 - 351]

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