ChemicalBook CAS DataBase List N-Ethylmaleimide

N-Ethylmaleimide synthesis

6synthesis methods

Product Name:N-Ethylmaleimide
CAS Number:128-53-0
Molecular formula:C6H7NO2
Molecular Weight:125.13

108-31-6 Synthesis

108-31-6
834 suppliers
$13.47/50 G

557-66-4 Synthesis

557-66-4
278 suppliers
$25.00/25g

128-53-0
249 suppliers
$5.00/250mg

Yield:-

Reaction Conditions:

with potassium acetate;acetic acid at 110; for 4 h;

Steps:

Step 1
General procedure: Methylamine hydrochloride (19.1 g, 0.30 moles) was added to a solution of acetic acid (40 ml), maleic anhydride (20 g, 0.20 moles) and potassium acetate (30.0 g, 0.30 moles) and the mass was stirred for 4 hrs at reflux temperature (110 ^oC). After completion of reaction, the mass was cooled to 25 - 30 ^oC. The reaction mass was poured, slowly, on to the chilled sodium bicarbonate solution (100 ml) and the product was extracted with diethylether (3 x 70 ml). The organic layer was washed with brine solution, dried over anhydrous sodium sulfate and solvent was removed under reduced pressure to afford 1-methyl pyrrole-2,5-dione (6.89 g, 30 %).

References:

Nirogi, Ramakrishna;Dwarampudi, Adireddy;Kambhampati, Ramasastry;Bhatta, Venugopalarao;Kota, Laxman;Shinde, Anil;Badange, Rajesh;Jayarajan, Pradeep;Bhyrapuneni, Gopinadh;Dubey [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 15,p. 4577 - 4580] Location in patent:supporting information; experimental part

FullText

109-96-6 Synthesis