ChemicalBook CAS DataBase List (+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT

(+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT synthesis

2synthesis methods

Product Name:(+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT
CAS Number:68935-27-3
Molecular formula:C30H32N2O8
Molecular Weight:548.58

32634-68-7 Synthesis

32634-68-7
470 suppliers
$5.00/5g

22083-74-5 Synthesis

22083-74-5
104 suppliers
$99.00/100mg

(+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT

68935-27-3
29 suppliers
$375.00/250mg

(-)-Nicotine (+)-O,O’-Di-p-toluoyl-D-tartaric Acid

68935-25-1
2 suppliers
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Yield:-

Reaction Conditions:

in ethanol;Reflux;

Steps:

1

A mixture of di-p-toluoyl-d-tartaric acid (23.8 g, 0.0617 mol), 100 ml ethanol, and (R,S)-nicotine (10 g, 0.0617 mol) was stirred for 1 hr, refluxed for 15 min, cooled to room temperature and stirred for 1 hr. The salt was filtered and further recrystallized using ethanol to obtain S-nicotine di-p-toluoyl-d-tartrate (10.5g, 62.1% yield). The salt was further treated as in example I to get (S)-nicotine (3 g, 60 % yield) 87.9 % chiral purity by HPLC.

References:

EP2484673,2012,A2 Location in patent:Page/Page column 6

25162-00-9
20 suppliers
$716.10/50MG

68935-27-3
29 suppliers
$375.00/250mg

68935-25-1
2 suppliers
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References

(+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT Related Search:

1-PYRIDIN-3-YL-ETHYLAMINE (R)-3-(pyrrolidin-2-yl)pyridine 3-(2-Pyrrolidinyl)pyridine (R)-(+)-2-BENZYLOXYPROPIONIC ACID (+/-)-NICOTINE D-Tartaric acid 2,3-Di-O-para-toluoyl-D-tartaric acid 1-PYRIDIN-3-YLPROPAN-1-AMINE