ChemicalBook CAS DataBase List Nicotinic acid

Nicotinic acid synthesis

14synthesis methods

Product Name:Nicotinic acid
CAS Number:59-67-6
Molecular formula:C6H5NO2
Molecular Weight:123.11

Nicotinic acid, pyridine-3-carboxylic acid (20.2.9) is synthesized industrially by heating a paraldehyde trimer of acetaldehyde, under pressure with ammonia, which leads to the formation of 2-methyl-5-ethylpyridine, followed by oxidation with nitric acid which gives the desired product.

108-99-6
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$9.00/5g

59-67-6
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$7.00/25g

Yield:59-67-6 99.58%

Reaction Conditions:

with oxygen;V₂O₅/Sb₂O₃-TiO₂ in water at 260 - 280;Industry scale;Inert atmosphere;Gas phase;

Steps:

8

The catalyst was prepared by the method as described in Example 3 and process conditions were maintained as per Example 5 except that the process was carried out at large scale. The catalyst was packed as per Example 5 in a tubular reactor. Total volume of the reactor was 75 liters and equipped with heating and cooling arrangement. The catalyst bed was heated in the presence of air/nitrogen to 250° C. β-picoline, water and air were fed separately through a vaporizer from top of the reactor. The molar feed ratio of oxygen:water:β-picoline was 20:40:1 and WHSV was 0.05 hr^-1. The nicotinic acid was isolated by the method as described in Example 4. The vent gases and scrubbed liquid obtained from secondary absorber and mother liquor of first absorber was recycled back in the process with optimum purge. The nicotinic acid obtained was white colored. Selectivity: 90.8%; β-picoline conversion of 94.6%. Assay: 99.58%.

References:

US2012/65405,2012,A1 Location in patent:Page/Page column 5

100-55-0 Synthesis