Propanoic acid, 2-bromo-3-oxo-, methyl ester synthesis
1synthesis methods
- Product Name:Propanoic acid, 2-bromo-3-oxo-, methyl ester
- CAS Number:20656-62-6
- Molecular formula:C4H5BrO3
- Molecular Weight:180.98
Yield:-
Reaction Conditions:
Stage #1:bromoacetic acid methyl ester with lithium diisopropyl amide
Stage #2:formic acid ethyl ester in tetrahydrofuran at -78 - 20;
References:
McIver, Edward G.;Bryans, Justin;Birchall, Kristian;Chugh, Jasveen;Drake, Thomas;Lewis, Stephen J.;Osborne, Joanne;Smiljanic-Hurley, Ela;Tsang, William;Kamal, Ahmad;Levy, Alison;Newman, Michelle;Taylor, Debra;Arthur, J. Simon C.;Clark, Kristopher;Cohen, Philip [Bioorganic and medicinal chemistry letters,2012,vol. 22,# 23,p. 7169 - 7173,5]