Pymetrozine synthesis
- Product Name:Pymetrozine
- CAS Number:123312-89-0
- Molecular formula:C10H11N5O
- Molecular Weight:217.23
500-22-1
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123313-07-5
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123312-89-0
244 suppliers
$96.40/250mg
Yield:123312-89-0 2080 g
Reaction Conditions:
in methanol at 65; for 12 h;Green chemistry;Large scale;Temperature;
Steps:
1.5 Example 1 Preparation of pymetrozine
(5) Preparation of pymetrozine: 5000ml three-necked flask into methanol (solvent) 1000ml, acetamidotriazinone1700g, 98wt% concentrated sulfuric acid 15g, stirring conditions, dropping saturated hydrogen chloride methanol solution 1100g, control the drop temperature40 , dropping time 2h, dropping finished to keep the temperature at 65 , holding 4h.Adjust the pH to 8, and then add 1070g of niacin, control the drop temperature at 65 , dropping time 3h, dropping finished to keep the temperature at 65 , the reaction 12h. Crystallization from 0 to -5 ° CHeart and dried to obtain 2080g of pymetrozine, the yield of 96%, recovery of by-product methyl acetate 740g, can be used for the synthesis of acetylHydrazine.
References:
CN103724327,2017,B Location in patent:Paragraph 0014; 0030; 0035; 0040-0042; 0043-0045; 0046-0048
500-22-1
460 suppliers
$6.00/5g
123313-07-5
1 suppliers
inquiry
123312-89-0
244 suppliers
$96.40/250mg