ChemicalBook CAS DataBase List PYRROLE-2-CARBONITRILE

PYRROLE-2-CARBONITRILE synthesis

10synthesis methods

Product Name:PYRROLE-2-CARBONITRILE
CAS Number:4513-94-4
Molecular formula:C5H4N2
Molecular Weight:92.1

1003-29-8
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$10.00/1g

4513-94-4
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$15.00/1g

Yield:4513-94-4 100%

Reaction Conditions:

Stage #1:2-pyrrole aldehyde with hydroxylamine-O-sulfonic acid in water at 20;
Stage #2: with potassium hydroxide in water at 0 - 20; for 4 h;

Steps:

M
Pyrrole-2-carboxaldehyde (3.00 g, 0.0316 mole) was combined with hydroxylamine- O-sulfonic acid (12.5 g, 0.11 mole) in 100 ml water and stirred at room temperature overnight. The reaction mixture was cooled to 0°C and a solution of potassium hydroxide (12.06 g, 0.603 mole) in 80ml water was added dropwise over 1 hour time period. The reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was extracted with dichloromethane (3 x 100 ml), the extract was dried over sodium sulfate (anh.). The solvent was removed to give 3.36 g of product as a liquid (yield: 100%)

References:

TIBOTEC PHARMACEUTICALS LTD. WO2006/35061, 2006, A1 Location in patent:Page/Page column 50

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