ChemicalBook CAS DataBase List (R)-3-(Boc-Amino)piperidine

(R)-3-(Boc-Amino)piperidine synthesis

10synthesis methods

Product Name:(R)-3-(Boc-Amino)piperidine
CAS Number:309956-78-3
Molecular formula:C10H20N2O2
Molecular Weight:200.28

454713-13-4
102 suppliers
$27.00/100mg

309956-78-3
552 suppliers
$11.00/5g

Yield:309956-78-3 97%

Reaction Conditions:

with 5%-palladium/activated carbon;hydrogen in ethanol at 20 - 25; under 150015 Torr; for 20 h;

Steps:

6 Example 6: Synthesis of R-3-(tert-butoxycarbonylamino)piperidine (7)

R-3-(tert-butoxycarbonylamino)-1-benzylpiperidine (20g) was dissolved in 96g of absolute ethanol, added with 5 mass% Pd/C (2g), passed into 20MPa hydrogen, and reacted at 20-25 °C. After 20 h, filtration and ethanol washing, the filtrate was combined and evaporated to dryness to give R-3-(tert-butoxycarbonylamino)piperidine (13.4 g), yield 97%.

References:

CN110078657,2019,A Location in patent:Paragraph 0135-0136