RU 58841 synthesis

4synthesis methods

Product Name:RU 58841
CAS Number:154992-24-2
Molecular formula:C17H18F3N3O3
Molecular Weight:369.34

RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography.
Alternative synthesis of the anti-baldness compound RU58841

654-70-6 Synthesis

654-70-6
467 suppliers
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154992-24-2
269 suppliers
$5.00/5mg

Yield:-

Steps:

Multi-step reaction with 7 steps
1.1: potassium carbonate / 1,2-dichloro-ethane / 14 h / 20 °C
2.1: sodium nitrite / N,N-dimethyl-formamide / 14 h / 20 °C
3.1: iron; hydrogenchloride / isopropyl alcohol; ethanol; water / 1 h / 90 °C
4.1: potassium carbonate / 1,2-dichloro-ethane / 14 h
5.1: sodium nitrite / N,N-dimethyl-formamide / 14 h / 20 °C
6.1: N,N-dimethyl-formamide / 7 h / 110 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h
7.2: 2 h / 50 °C

References:

Leonard, Matthew J.;Lingham, Anthony R.;Niere, Julie O.;Jackson, Neale R. C.;McKay, Peter G.;Huegel, Helmut M. [RSC Advances,2014,vol. 4,# 27,p. 14143 - 14148]

4753-59-7
158 suppliers
$10.00/5g

4-(4,4-DiMethyl-2,5-dioxoiMidazolidin-1-yl)-2-trifluoroMethylbenzonitrile

143782-20-1
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154992-24-2
269 suppliers
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References

Propanamide, 2-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyl-

1259327-69-9
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154992-24-2
269 suppliers
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References

2-Amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide

208122-09-2
3 suppliers
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154992-24-2
269 suppliers
$5.00/5mg

References

RU 58841 Related Search:

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