ChemicalBook CAS DataBase List S,S-dimethyl sulfoximine

S,S-dimethyl sulfoximine synthesis

5synthesis methods

Product Name:S,S-dimethyl sulfoximine
CAS Number:1520-31-6
Molecular formula:C2H7NOS
Molecular Weight:93.15

67-68-5 Synthesis

67-68-5
1203 suppliers
$15.00/100g

1520-31-6
98 suppliers
$14.00/100mg

Yield:1520-31-6 87%

Reaction Conditions:

with sodium azide;sulfuric acid in dichloromethane at 0 - 35;

Steps:

19.1 First step: iminodimethyl-λ6-sulfanone
Dimethyl sulfoxide (5 g, 64 mmol) was dissolved in dichloromethane (40 mL), sodium azide (4.4 g, 68 mmol) was added at 0 ° C, and concentrated sulfuric acid (13 mL) was added dropwise. The reaction was stirred at 35 ° C overnight, the reaction solution was poured into ice water (100 g), the aqueous layer was separated, and the aqueous layer was evaporated to dryness. The mixture was stirred for 30 minutes with ethanol (100 mL), filtered, and the filtrate was evaporated to dryness. It was beaten for 30 minutes, filtered, and the filtrate was dried to give iminodimethyl-[lambda]6-sulfanone (5.2 g, yield 87%).[0472]1H NMR (400 MHz, CDCl3) δ 3.09 (s, 6H), 2.68 (brs, 1H).

References:

JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.;SHANGHAI HANSOH BIOMEDICAL CO., LTD.;SU, Yidong;GU, Peng;CHEN, Xiaopo;LIU, Lei;BAO, Rudi WO2018/130174, 2018, A1 Location in patent:Page/Page column 50

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