ChemicalBook CAS DataBase List Tetrahydro-4H-pyran-4-one

Tetrahydro-4H-pyran-4-one synthesis

7synthesis methods

Product Name:Tetrahydro-4H-pyran-4-one
CAS Number:29943-42-8
Molecular formula:C5H8O2
Molecular Weight:100.12

In organic synthesis, Tetrahydro-4H-pyran-4-one participates in a variety of cycloaddition reactions and is used as a building block for many more complex chemical structures. The synthesis Tetrahydro-4H-pyran-4-one is as follows: Add tetrahydropyran-4-one to a mixed solvent of toluene and methanol, add hydrogenate at room temperature, press filter, and concentrate the filtrate to dryness, then rectification to give tetrahydropyrone in a yield of 86%.

124-38-9
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111-44-4 Synthesis

111-44-4
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29943-42-8
418 suppliers
$5.00/1g

Yield:29943-42-8 95.9%

Reaction Conditions:

with cesium iodide in ethanol;water at 90; under 8250.83 Torr;Temperature;Pressure;

Steps:

1.2; 2.2; 3.2; 4.2; 5.2
(2) dissolving bis(2-chloroethyl)ether in ethanol, Adding Zr-Ce-Ti-Al composite oxide and cesium iodide, heating to 90 °C, Add H2O and introduce CO2 under stirring. The control pressure is 1.1 MPa, after the reaction is completed, Drop to room temperature, filter, and distill off ethanol and H2O under reduced pressure.After recrystallization, tetrahydropyran-4-one is obtained. Step (2) The molar ratio of bis(2-chloroethyl)ether to ethanol is 1.5 mol/L; the mass ratio of bis(2-chloroethyl)ether to Zr-Ce-Ti-Al composite oxide 5:2, the mass ratio of Zr-Ce-Ti-Al composite oxide to cesium iodide is 9:2; the flow rate of CO2 is 35L/min; recrystallization is carried out by ethyl acetate/petroleum ether system Recrystallization. The tetrahydropyran-4-one obtained had a purity of 99.7% and a product yield of 95.9%.

References:

Suzhou Gaide Careful Materials Co., Ltd.;Li Xiaoming CN108912081, 2018, A Location in patent:Page/Page column 4-6

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