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ChemicalBook CAS DataBase List Trityl Olmesartan Medoxomil

Trityl Olmesartan Medoxomil synthesis

11synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1: 86 percent / HCl / Ambient temperature
2: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C
3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
4: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature
5: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C

References:

Yanagisawa, Hiroaki;Amemiya, Yoshiya;Kanazaki, Takuro;Shimoji, Yasuo;Fujimoto, Koichi;Kitahara, Yoshiko;Sada, Toshio;Mizuno, Makoto;Ikeda, Masahiro;Miyamoto, Shuichi;Furukawa, Youji;Koike, Hiroyuki [Journal of Medicinal Chemistry,1996,vol. 39,# 1,p. 323 - 338]

133051-88-4 Synthesis
5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole

133051-88-4
91 suppliers
$71.00/50 mg

144689-93-0 Synthesis
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

144689-93-0
472 suppliers
$16.00/5g

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