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Faropenem sodium hemipentahydrate

Faropenem sodium hemipentahydrate Struktur
106560-14-9
CAS-Nr.
106560-14-9
Englisch Name:
Faropenem sodium hemipentahydrate
Synonyma:
FROPENEM;FAROPENEM;Faropenem sodium hemi 5-hydrate;Faropenem sodium hemipentahydrate;Faropenem sodium hemipentahydrate USP/EP/BP;6α-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;(5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid;6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-2-oxolanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CBNumber:
CB1300660
Summenformel:
C12H15NO5S
Molgewicht:
285.32
MOL-Datei:
106560-14-9.mol
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Faropenem sodium hemipentahydrate Eigenschaften

Siedepunkt:
570.2±50.0 °C(Predicted)
Dichte
1.56±0.1 g/cm3(Predicted)
pka
4.00±0.40(Predicted)
CAS Datenbank
106560-14-9
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Faropenem sodium hemipentahydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Farom was launched in Japan for use as an antibiotic against common respiratory tract pathogens. It can be prepared by several related routes of about seven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylated azetidinone. It is a broad spectrum oral penem antibiotic that is β-lactamase stable. Farom is the most active β-lactam against anaerobes (more than cefaclor, cefixime and amoxicillin) but also has activity against Gram-positive, Gram-negative and enterobacteriaceae. It is equally active against strains carrying plasmid and chromosome mediated β-lactamases. The short plasma elimination half-life is the result of hydrolysis by renal dehydropeptidase. It is more stable to hydrolysis by extended spectrum β-lactamases than some second and third generation cephalosporins.

Verwenden

Treatmentof bacterial infections.

Antimicrobial activity

An orally active penem with a broad spectrum of antibacterial activity, including activity against selected anaerobic pathogens. Although it is active against most enterobacteria, it has reduced activity against Ser. marcescens, Enterobacter spp. and some Providencia spp. It generally retains activity against many Gram-positive organisms, but has no useful activity against Ps. aeruginosa. It has reduced activity against E. faecium, methicillin-resistant Staph. aureus (MRSA) and some strains of coagulase-negative staphylococci. It is stable to hydrolysis by extended spectrum β-lactamases, but is hydrolyzed by carbapenemases. Esterified prodrugs with increased bioavailability have been studied in clinical trials but have not received regulatory approval.

Faropenem sodium hemipentahydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Triphenylmethanthiol Triethylphosphat Silbernitrat Ethyldiisopropylamin Tetrabutylammoniumperiodat Oxalyldichlorid Chlormethan

Downstream Produkte

Faropenem sodium hemipentahydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 135)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21688 55
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845
 sales@amoychem.com China 6387 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49391 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051
 joe@yuhengpharm.com CHINA 21149 58
SIMAGCHEM CORP 		+86-13806087780
 sale@simagchem.com China 17367 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167
 1026@dideu.com China 9126 58
AFINE CHEMICALS LIMITED 		0571-85134551 18958018566;
 info@afinechem.com China 15377 58

106560-14-9()Verwandte Suche:

Natriumhydrogencarbonat Furazolidon (o-(-2,6-Dichloranilino)phenyl)-essigsäure, Natrium-Salz 5-Chlorvaleriansaeure Tetrahydrofuran Natriumhydroxid Trinatriumcitrat 4,4-Bis(4-hydroxyphenyl)valeriansure Natriumacetat Natriumbenzoat 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol Natriumchlorit Pralmorelin 2-(Methylsulfonyl)ethanol Natriumchlorid Natriumsulfat 2-Ethyl-3-hydroxy-4H-pyran-4-on Dinatriumcarbonat, Verbindung mitHydrogenperoxid (2:3)
  • [5R-[3(R^<*>^)，5α，6α(R^<*>^)]]-6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azobicyclo[3.2.0]leapt-2- ene-2-carboxylicacid
  • (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-keto-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid
  • (+)-(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid
  • 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, [5R-[3(R*),5α,6α(R*)]]-
  • 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, (5R,6S)-
  • 6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt hemipentahydrate
  • Faropenem sodium hemipentahydrate
  • FAROPENEM
  • FROPENEM
  • (5R,6R)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-2-oxolanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • 6α-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid
  • Faropenem sodium hemipentahydrate USP/EP/BP
  • (5R,6S)-6-((R)-1-Hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • Faropenem-d5Q: What is Faropenem-d5 Q: What is the CAS Number of Faropenem-d5 Q: What are the applications of Faropenem-d5
  • Faropenem sodium hemi 5-hydrate
  • 106560-14-9
  • 22547-49-3
  • 2C12H14NNaO5S5H20
  • 2C12H14NO5S2Na5H2O
  • API
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