ALPHA-APO-OXYTETRACYCLINE manufacturers
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| | ALPHA-APO-OXYTETRACYCLINE Basic information |
| | ALPHA-APO-OXYTETRACYCLINE Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 63 | | Safety Statements | 45-36/37 | | HS Code | 29413020 |
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ACROS
| English |
| | ALPHA-APO-OXYTETRACYCLINE Usage And Synthesis |
| Description | β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis. | | Chemical Properties | yellow-brown to brown powder | | Uses | β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability. | | Uses | β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability. | | Uses | Oxytetracycline metabolite (absolute stereochemistry unknown) |
| | ALPHA-APO-OXYTETRACYCLINE Preparation Products And Raw materials |
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