| Identification | Back Directory | [Name]
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α | [CAS]
1027401-98-4 | [Synonyms]
DSVAWVBHUBDAPY-AHJNKEMKSA-N
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α
7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pentyl)cyclopentyl)heptanoic acid
Cyclopentaneheptanoic acid, 3,5-dihydroxy-2-[(3R)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pentyl]-, (1R,2R,3R,5S)- | [Molecular Formula]
C24H35F3O5 | [MDL Number]
MFCD05863947 | [MOL File]
1027401-98-4.mol | [Molecular Weight]
460.53 |
| Hazard Information | Back Directory | [Description]
A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2α derivatives have been approved for the treatment of glaucoma.1,2,3 These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.4 17-trifluoromethylphenyl-13,14-dihydro trinor PGF1α (17-TFM-PGF1α) is a typical “ring” analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1α is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding.5 As an ocular hypotensive agent, it is expected that 17-TFM-PGF1α would act very much like the free acid of latanoprost. | [Definition]
ChEBI: 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1alpha is a prostanoid. | [References]
1. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of bimatoprost (Lumigan?) Surv. Ophthalmol. 45(Suppl 4),S337-S345(2001).
2. Stjernschantz, J.W. From PGF2α-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lecture Invest. Ophthalmol. Vis. Sci. 42(6),1134-1145(2001).
3. Sorbera, L.A., and Casta?er, J. Travoprost Drugs Future 25(1),41-45(2000).
4. Resul, B., Stjernschantz, J., No, K., et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents J. Med. Chem. 36,243-248(1993).
5. deLong, M.A., Amburgey, J., Taylor, C., et al. Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues Bioorg. Med. Chem. Lett. 10,1519-1522(2000). |
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