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104104-50-9

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104104-50-9 Structure

104104-50-9 Structure
IdentificationBack Directory
[Name]

SR-95531
[CAS]

104104-50-9
[Synonyms]

GABAZINE
SR-95531
GABAZINE BROMIDE
Gabazine Hydrobromide
SR 95531 HYDROBROMIDE
SR 95531 hydrobromide NEW
2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br
2-(3-CARBOXYPROPYL)-3-AMINO-6-(4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE
6-IMINO-3-(4-METHOXYPHENYL)-1(6H)-PYRIDAZINEBUTANOIC ACID HYDROBROMIDE
6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide
4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide
1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide
Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide
[Molecular Formula]

C15H18BrN3O3
[MDL Number]

MFCD00055135
[MOL File]

104104-50-9.mol
[Molecular Weight]

368.23
Chemical PropertiesBack Directory
[Melting point ]

200 °C(Solv: ethanol (64-17-5))
[storage temp. ]

Store at RT
[solubility ]

DMSO: 30 mg/mL
[form ]

solid
[color ]

white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P305+P351+P338
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABAA receptors (Ki = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABAA receptor isoforms from mice, rats, and humans.
[Uses]

Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.
[Biological Activity]

Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.
[Biochem/physiol Actions]

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.
[storage]

Room temperature
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