| Identification | Back Directory | [Name]
MAGAININ II | [CAS]
108433-95-0 | [Synonyms]
Aids007842
MAGAININ 2
Aids-007842
MAGAININ II
Magainin II peptide
MAGAININ II USP/EP/BP
GIGKFLHSAKKFGKAFVGEIMNS
Magainin II, ≥97% (HPLC)
Magainin 2 peptide, Xenopus
Magainin 2 (Xenopus laevis)
WO2011023702 SEQID: 10 claimed protein
Magainin I, 10-L-lysine-22-L-asparagine-
96: PN: WO2009015163 SEQID: 98 unclaimed protein
GLY-ILE-GLY-LYS-PHE-LEU-HIS-SER-ALA-LYS-LYS-PHE-GLY-LYS-ALA-PHE-VAL-GLY-GLU-ILE-MET-ASN-SER
Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH
H-GLY-ILE-GLY-LYS-PHE-LEU-HIS-SER-ALA-LYS-LYS-PHE-GLY-LYS-ALA-PHE-VAL-GLY-GLU-ILE-MET-ASN-SER-OH
Gly-L-Ile-Gly-L-Lys-L-Phe-L-Leu-L-His-L-Ser-L-Ala-L-Lys-L-Lys-L-Phe-Gly-L-Lys-L-Ala-L-Phe-L-Val-Gly-L-Glu-L-Ile-L-Met-L-Asn-L-Ser-OH | [Molecular Formula]
C114H180N30O29S | [MDL Number]
MFCD00133522 | [MOL File]
108433-95-0.mol | [Molecular Weight]
2466.9 |
| Chemical Properties | Back Directory | [Boiling point ]
2444.0±65.0 °C(Predicted) | [density ]
1.275±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [Sequence]
H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH |
| Hazard Information | Back Directory | [General Description]
Magainin II is a member of the antimicrobial peptides family. It is a cationic peptide with Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser amino acid sequence. Magainin II is water soluble and non-hemolytic at its effective and amphiphilic antimicrobial concentrations. | [Biochem/physiol Actions]
Magainin II acts as an antibiotic in a variety of organisms. Magainin II exhibits cytotoxic and anti-proliferative effects via pore formation in bladder cancer cells. In mice, it acts as an anti-tumor agent in several cancer cell lines and tumors. Magainin II facilitates lactate dehydrogenase discharge from mammalian cells. It directly interacts with certain cell membranes via amphiphilic α-helix and forms permeable ion channels, which results in depolarization and irreversible cytolysis and finally cell death. At low concentrations, Magainin II retards the growth of bacterial and fungal species and it promotes cytolysis in protozoa. | [storage]
-20°C, protect from light |
|
|